{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:41:08Z","timestamp":1781577668024,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To investigate the amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one-night polysomnography, followed by a modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude, and phase. Participants with IH, diagnosed according to the International Classification of Sleep Disorders-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided into four groups based on their mMSLT mean sleep latency (mMSLT+,\u22648 minutes) and their BR total sleep time (BR+, \u226519 hours).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 108 participants (80% women, 28.3\u2005\u00b1\u20057.8 years old) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), and 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH, and HC, nor in the subgroup analysis (37 BR+\/mMSLT+, 35 BR+\/mMSLT\u2212, 9 BR-\/mMSLT+, 27 BR-\/mMSLT\u2212). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH, and HC, and was not related to prolonged sleep time or objective daytime sleepiness.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae246","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T17:54:48Z","timestamp":1729533288000},"source":"Crossref","is-referenced-by-count":10,"title":["Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: a case\u2013control study"],"prefix":"10.1093","volume":"48","author":[{"given":"Tugdual","family":"Adam","sequence":"first","affiliation":[{"name":"Institute of Neurosciences of Montpellier (INM), University of Montpellier, INSERM 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