{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:59:26Z","timestamp":1792465166014,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is characterized by disordered breathing during sleep and is associated with major cardiovascular complications. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) as an important treatment for obesity and diabetes mellitus show promising therapeutic prospects in OSA. We conducted a meta-analysis to evaluate the effect of GLP-1RA intervention in OSA individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed and Web of Science databases (published until July 1, 2024). The included studies evaluated the GLP-1RA in OSA individuals and the efficacy outcomes measured by the apnea-hypopnea index (AHI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six studies with a total of 1067 participants enrolled. GLP-1RA significantly decreased AHI with an estimated treatment difference of \u22129.48 events per hour (95% confidence interval [CI] = \u2005\u221212.56 to\u2005\u2212\u20056.40, I2\u2005=\u200592%). The change in weight was \u221210.99 kg and body mass index (BMI) was \u20131.60 kg\/m2. The mean difference in systolic blood pressure was \u20134.81 mmHg and in diastolic blood pressure was \u20130.32 mmHg. Tirzepatide significantly reduced AHI more than liraglutide with an estimated treatment difference of \u201321.86 events per hour (95% CI = \u201325.93 to \u201317.79) vs \u20135.10 events per hour (95% CI = \u20136.95 to \u20133.26). Obese individuals experienced a more significant decrease in AHI with an estimated treatment difference of \u201312.93 events per hour vs \u20134.31 events per hour. The application of continuous positive airway pressure and the duration of follow-up did not affect the therapeutic effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP-1RA could significantly reduce the severity of OSA, and also lead to weight loss and lower blood pressure. Further high-quality randomized controlled trials (RCTs) are needed to explore different GLP-1RA treatments and durations in OSA and identify participant subgroups that may benefit the most.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsae280","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T23:22:44Z","timestamp":1732749764000},"source":"Crossref","is-referenced-by-count":60,"title":["Glucagon-like peptide-1 receptor agonists for the treatment of obstructive sleep apnea: a meta-analysis"],"prefix":"10.1093","volume":"48","author":[{"given":"Mingxia","family":"Li","sequence":"first","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Yang","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-0127","authenticated-orcid":false,"given":"Fangfang","family":"Ge","sequence":"additional","affiliation":[{"name":"Xi\u2019an International Medical Center Hospital , Xi\u2019an city ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"issue":"14","key":"2025041104530802600_CIT0001","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","article-title":"Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. 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