{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:42:36Z","timestamp":1768002156516,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Wellcome Trust Investigator","award":["210684\/Z\/18\/Z"],"award-info":[{"award-number":["210684\/Z\/18\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Melanopsin-expressing retinal ganglion cells, which provide light information to time sleep and entrain circadian clocks, also influence perceived brightness raising the possibility that psychophysical paradigms could be used to explore the origins and implications of variability in melanopic sensitivity. We aimed to develop accessible psychophysical tests of melanopic vision and relate outcomes with a pupillometric measure of melanopsin function (post-illumination pupil response) and prior light exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Individually calibrated pairs of isoluminant stimuli differing in melanopic radiance from a four primary source were presented sequentially with superimposed random color offsets in a two alternative forced choice brightness preference paradigm to 41 na\u00efve adult participants with personal light exposure data for the prior 7 days and post-illumination pupil response measures defined by comparing maintained pupil constriction for luminance matched \u201cred\u201d vs \u201cblue\u201d pulses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Across participants we observed the expected tendency to report positive melanopsin contrast stimuli as \u201cbrighter\u201d (one-tailed t-test p\u2005&amp;lt;\u20050.001), but with substantial inter-individual variability in both sensitivity (melanopsin contrast at criterion preference p\u2005=\u20050.75) and amplitude (preference at maximum melanopic contrast). There was little correlation between these psychophysical outcomes and post-illumination pupil response magnitude, or between either psychophysical or post-illumination pupil response measures and light history metrics (pairwise Pearson correlation coefficients -0.5&amp;gt;\u2005&amp;lt;\u20050.5). Random forest machine learning failed to satisfactorily predict outcome for either psychophysical or post-illumination pupil response measures based upon these inputs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings reveal that estimates of melanopic function provided by perceptual and pupillometric paradigms can be largely independent of one another and of recent history of light exposure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae289","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T04:05:31Z","timestamp":1734149131000},"source":"Crossref","is-referenced-by-count":1,"title":["Pupillometric and perceptual approaches provide independent estimates of melanopsin activity in humans"],"prefix":"10.1093","volume":"48","author":[{"given":"Tom","family":"Woelders","sequence":"first","affiliation":[{"name":"Division 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Neuroscience , T\u00fcbingen ,","place":["Germany"]},{"name":"Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Diabetes Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology Medicine and Health, Centre for Biological Timing, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Lucas","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, School of Biological Sciences, Faculty of Biology Medicine and Health, Centre for Biological Timing, University of Manchester , Manchester 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