{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:48:52Z","timestamp":1791841732824,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinician Scientist Award from the National Medical Research Council of Singapore","award":["CSASI18may-0001"],"award-info":[{"award-number":["CSASI18may-0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>We compared mandibular advancement device (MAD) versus continuous positive airway pressure (CPAP) on quality-of-life (QoL) in a prespecified analysis of the CRESCENT trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred and twenty participants over age 40 with Obstructive sleep apnea (OSA), hypertension, and increased cardiovascular risk from three public hospitals were randomly assigned to MAD or CPAP (1:1). Multi-dimensional QoL questionnaires were administered at baseline, 6 months, and 12 months. Three sleep-related QoL questionnaires: Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), and Sleep Apnea Quality of Life Index (SAQLI). Two generic QoL questionnaires: EuroQoL 5-D (EQ-5D) and Short Form 36 Health Survey (SF36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MAD adherence was 5.5 (3.9\u20136.9) hours at 6 months and 5.0 (3.3\u20136.1) hours at 12 months. CPAP adherence was 4.9 (3.3\u20136.1) hours at 6 months and 4.8 (3.3\u20135.7) hours at 12 months. Both groups showed improvements in sleep-related QoL. ESS improved at 6 and 12 months (p\u2005&amp;lt;\u2005.001), with a between-group difference favoring CPAP at 6 months (\u0394 1.45 [0.44 to 2.46], p\u2005=\u2005.005). FOSQ improved at 6 and 12 months (p\u2005&amp;lt;\u2005.001), with a between-group difference favoring CPAP at 12 months (\u0394 \u22120.91 [\u22121.77 to \u22120.05], p\u2005=\u2005.038). SAQLI improved at 6 and 12 months (p\u2005&amp;lt;\u2005.001) without between-group differences. For generic QoL questionnaires, SF-36 improved in most domains at 6 and 12 months, with the Social Functioning section favoring CPAP at 12 months (p\u2005=\u2005.013). EQ-5D improved at 12 months, with a trend favoring CPAP (p\u2005=\u2005.053).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MAD and CPAP effectively improved sleep-related QoL and some aspects of generic QoL. CPAP improved sleep-related QoL to a greater extent than MAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Name<\/jats:title>\n                    <jats:p>The Cardiosleep Research Program on OSA, Blood Pressure Control and Maladaptive Myocardial Remodeling\u2014Non-inferiority Trial (CRESCENT). URL: https:\/\/clinicaltrials.gov\/study\/NCT04119999?locStr=Singapore&amp;country=Singapore&amp;cond=Obstructive%20Sleep%20Apnea&amp;aggFilters=ages:adult%20older,studyType:int&amp;rank=6<\/jats:p>\n                    <jats:p>TRIAL REGISTRATION: NCT04119999.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaf022","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:25:39Z","timestamp":1738221939000},"source":"Crossref","is-referenced-by-count":6,"title":["Patient-reported quality of life outcomes with mandibular advancement versus continuous positive airway pressure: insights from the CRESCENT trial"],"prefix":"10.1093","volume":"48","author":[{"given":"Juliana Tereza","family":"Colpani","sequence":"first","affiliation":[{"name":"Department of Endodontics, Operative Dentistry and Prosthodontics, Faculty of Dentistry, National University of Singapore 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