{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:40:00Z","timestamp":1788316800569,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["12A1-CGGP06-051"],"award-info":[{"award-number":["12A1-CGGP06-051"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>To examine the pattern of sedative-hypnotic prescriptions associated with the risk of suicidal behavior among older adults with and without insomnia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 8319 suicide cases and age- and sex-matched controls from the population-wide National Health Insurance Research Database. Suicide methods and insomnia were defined using diagnostic codes. The sedative-hypnotic use pattern was categorized by half-life, prescription volume measured in defined daily doses (DDDs), and its temporal relationship with suicide. Odds ratios were employed to assess the risk of insomnia and the prescription patterns of sedative-hypnotics on suicide. Additionally, we compared suicide methods between sedative-hypnotic users and nonusers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Insomnia was mildly associated with suicide behavior after adjusting for mental illnesses (adjusted relative risk [RR]\u2005=\u20051.82, OR\u2005=\u20051.86, 95% confidence interval [CI]\u2005=\u20051.76 to 1.97), but the prescription of sedative-hypnotics was associated with 5-fold suicide risk (adjusted RR\u2005=\u20055.22, OR\u2005=\u20055.90, 95% CI\u2005=\u20055.11 to 6.82). Among patients with insomnia, a prescription volume of \u226531 DDDs per year and a prescription within 90 days of the suicide index date were associated with increased suicide risk. Individuals prescribed sedative-hypnotics were more likely to commit suicide by methods involving sedative-hypnotic poisoning (21% vs. 0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among older adults, sedative-hypnotic prescription is associated with increased suicide risk and suicide by self-poisoning using such medications. Non-pharmacological treatment for insomnia, such as cognitive-behavioral therapy, is essential for suicide prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaf136","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:09:29Z","timestamp":1747818569000},"source":"Crossref","is-referenced-by-count":5,"title":["Sedative-hypnotics are associated with additional risk of suicide in older adults: a population-based case\u2013control study"],"prefix":"10.1093","volume":"49","author":[{"given":"Hang-Ju","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Jen-Ai Hospital Dali Branch , Taichung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Management Office for Health Data, China Medical University Hospital , Taichung ,","place":["Taiwan"]},{"name":"College of Medicine, China Medical University , Taichung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-7584","authenticated-orcid":false,"given":"Wan-Ju","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Center for Geriatrics and Welfare Research, National Health Research Institutes , Miaoli County ,","place":["Taiwan"]},{"name":"Department of Psychiatry, China Medical University Hospital , Taichung ,","place":["Taiwan"]},{"name":"Department of Public Health, China Medical University , Taichung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"issue":"3","key":"2026051111185576600_CIT0001","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3390\/ijerph9030760","article-title":"Suicide in the world","volume":"9","author":"Varnik","year":"2012","journal-title":"Int J Environ Res Public Health."},{"issue":"2","key":"2026051111185576600_CIT0002","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1080\/13607863.2015.1083945","article-title":"A systematic review of physical illness, functional disability, and suicidal behaviour among older adults","volume":"20","author":"Fassberg","year":"2016","journal-title":"Aging Ment Health."},{"issue":"3","key":"2026051111185576600_CIT0003","doi-asserted-by":"publisher","first-page":"249","DOI":"10.4103\/0019-5545.166614","article-title":"Risk factors for suicide in elderly in comparison to younger age groups","volume":"57","author":"Suresh Kumar","year":"2015","journal-title":"Indian J Psychiatry"},{"issue":"2","key":"2026051111185576600_CIT0004","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cger.2018.01.008","article-title":"Sleep Disorders in the elderly","volume":"34","author":"Yaremchuk","year":"2018","journal-title":"Clin Geriatr Med."},{"issue":"2","key":"2026051111185576600_CIT0005","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.maturitas.2014.04.003","article-title":"Suicidal behaviour and suicide prevention in later life","volume":"79","author":"Draper","year":"2014","journal-title":"Maturitas."},{"issue":"2","key":"2026051111185576600_CIT0006","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1017\/s1041610295001943","article-title":"Suicide and aging. 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