{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:23:53Z","timestamp":1781148233498,"version":"3.54.1"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fondation pour l\u2019Avenir"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Current treatments for narcolepsy type 1 (NT1) have little impact on psychiatric, cognitive, and metabolic comorbidities. Here, we evaluated the feasibility, safety, and efficacy of a prospective exercise training (ET) program on sleep-related symptoms and comorbidities in NT1. Sedentary adult with NT1 participated in a 6-week supervised ET program followed by a 18-week self-directed program. Outcomes included the Narcolepsy Severity Scale (NSS), Hospital Anxiety and Depression Scale, Insomnia Severity Index (ISI), cardiometabolic parameters (body mass index [BMI], glycemia, insulin, C-reactive protein, lipid panel with insulin resistance [IR] [TG\/HDL-C] and cardiovascular risk [Total-C\/HDL-C] markers), cardiorespiratory fitness, and attention (Bron\/Lyon Attention Stability Test). Wilcoxon tests compared baseline, 6-week, and 6-month data. Among 30 participants (73.3% women, 39.8\u2009\u00b1\u200913.9\u00a0years, BMI\u2009=\u200931.0\u2009\u00b1\u20095.1\u00a0kg\/m2), 25 completed the 6-month program. Of the 379 supervised sessions (84.2% attendance), only seven partial cataplexies occurred. At 6\u00a0weeks, significant improvements were observed in median[IQR] NSS (\u22122.0[\u22124.0;0], p=.046), ISI (\u22121.0[\u22123.0;1.0], p=.050), triglycerides (\u22120.21[\u22120.46;\u22120.09]g\/L, p=.015), IR (\u22120.19[\u22120.46;\u22120.04], p=.003), cardiorespiratory fitness (+15.0[5.0;20.0]watts, p&amp;lt;.001), and in most attention scores (stability, intensity, reaction time: p&amp;lt;.05). At 6\u00a0months, NSS and ISI changes were no longer significant but anxiety (\u22121.0[\u22123.0;1.0], p=.041) and depression (\u22122.0[\u22124.0;0.0], p=.004) decreased. Improvements in IR (\u22120.27[\u22120.44;\u22120.11], p=.002), triglycerides (\u22120.2[\u22120.4;0.0]g\/L, p=.033), cardiovascular risk (\u22120.16[\u22120.41;\u22120.02], p=.019), and attention scores (intensity, reaction time, number of errors p&amp;lt;.05) were sustained. VO2max and BMI showed no significant changes. Physical activity is feasible and safe in NT1, enabling improvements in narcolepsy symptoms, anxiety\/depression, cognition, and cardiometabolic markers. Larger randomized controlled trials are needed to confirm these findings.<\/jats:p>\n                  <jats:p>Clinical Trial: NARCOSPORT NCT05460052.<\/jats:p>","DOI":"10.1093\/sleep\/zsaf272","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:28:52Z","timestamp":1757417332000},"source":"Crossref","is-referenced-by-count":2,"title":["Feasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study"],"prefix":"10.1093","volume":"49","author":[{"given":"Fran\u00e7ois","family":"Ricordeau","sequence":"first","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-2252","authenticated-orcid":false,"given":"Emeric","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Laboratory LIBM EA7424, Team Vascular Biology and Red Blood Cell, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Putois","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Faculty of Psychology, UniDistance Suisse , Brig ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Jaffiol","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Pediatric Sleep Unit, Hospital for Women Mothers & Children, Lyon 1 University, France , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-3686","authenticated-orcid":false,"given":"Anne","family":"Cheylus","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4303-2690","authenticated-orcid":false,"given":"Gabrielle","family":"Pouilloux","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Hoarau","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bastuji","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Franco","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Pediatric Sleep Unit, Hospital for Women Mothers & Children, Lyon 1 University, France , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Herbillon","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon ,","place":["France"]},{"name":"Pediatric Sleep Unit, Hospital for Women Mothers & Children, Lyon 1 University, France , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Capelle","sequence":"additional","affiliation":[{"name":"AGIR \u00e0 dom , Saint-Priest ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Joubert","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Pradat","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon 1 University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University , Lyon 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