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Participants underwent five recurring 6-hour\u00a0cycles of 2-hour sleep opportunities and 4-hour standardized wake episodes. After 90\u00a0minutes of awakening during each wake episode, participants performed 30\u00a0minutes of moderate-intensity aerobic exercise at 40% heart-rate-reserve. Systolic, diastolic, and mean BP and hemodynamic determinants derived from the beat-to-beat BP waveform (finger photoplethysmography) were measured just before and 30\u00a0minutes after the conclusion of each exercise bout. Arm and leg blood flows were assessed using vascular ultrasound. Endogenous circadian phases were determined using each participant\u2019s dim-light melatonin onset. Mixed-model cosinor analyses were used to test for the presence of circadian rhythmicity (with significance set at p&amp;lt;.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-exercise systolic BP reduction and mean BP reduction had significant circadian rhythms, with the greatest decreases at the circadian phase corresponding to ~1\u00a0p.m. (\u221210 and \u22129\u00a0mmHg), respectively. Systemic vascular resistance and leg blood flow also had significant circadian rhythms, with the lowest resistance and greatest blood flow at ~11\u00a0a.m.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In young, healthy adults, the circadian system modulates the post-exercise BP reduction, likely due to skeletal muscle vasodilatory mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaf295","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:44:17Z","timestamp":1758627857000},"source":"Crossref","is-referenced-by-count":4,"title":["Circadian mechanisms underlying post-exercise blood pressure responses in healthy adults"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-7390","authenticated-orcid":false,"given":"Leandro 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