{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:52:22Z","timestamp":1791075142746,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009886","name":"AASM","doi-asserted-by":"publisher","award":["188-SR-17, SR-2217"],"award-info":[{"award-number":["188-SR-17, SR-2217"]}],"id":[{"id":"10.13039\/100009886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["19CDA34660137"],"award-info":[{"award-number":["19CDA34660137"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL153874, R21 HL161766"],"award-info":[{"award-number":["R01HL153874, R21 HL161766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009886","name":"American Academy of sleep Medicine","doi-asserted-by":"publisher","award":["AASM, 335-FP-24"],"award-info":[{"award-number":["AASM, 335-FP-24"]}],"id":[{"id":"10.13039\/100009886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Respiratory event-related leg movements (RRLMs) in obstructive sleep apnea may reflect event severity and predict adverse outcomes. This study examines the association between RRLM frequency and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sample of 571 men (median [IQR] age: 76.0 [72.0\u201381.0] years; BMI: 28.0 [25.0\u201330.0] kg\/m2) with an apnea\u2013hypopnea index (AHI, \u22653 per cent desaturation) \u226510 events\/h was selected based on available incident data and annotations of RRLMs, from the Osteoporotic Fractures in Men Studies . RRLMs were scored if they occurred within \u00b15\u00a0s of respiratory event termination lasting 0.5\u201310\u00a0s; the average number of RRLMs per hour of sleep respiratory-related leg movement index (RRLMI) was measured. For comparison, the number of periodic leg movements of sleep (PLMS) per hour of sleep (PLMI) was also quantified. Cox regression models estimated the adjusted hazard ratios (aHR) for mortality per SD increase in RRLMI and PLMI. Secondary analyses assessed the relationship between RRLM duration (i.e. a measure of RRLM strength) and measures of event severity (i.e. desaturation area, arousal, heart rate response, and event duration).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 287 all-cause deaths during 11.4 [6.9;12.5] years of follow-up. RRLMI and PLMI were 6.0 [3.4;9.3] and 22.0 [2.0;54.0] events\/h, respectively. In an adjusted model, every 1SD increase in RRLMI was associated with all-cause mortality (aHR: 1.17 [95% CI: 1.01\u20131.34], p-value\u2009=\u2009.03). In contrast, PLMI was not associated with mortality (aHR: 1.04 [95% CI: 0.92\u20131.17], p-value\u2009=\u2009.5). Furthermore, RRLM duration was linked to measures of event severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a sample of older men with obstructive sleep apnea, RRLMI was independently associated with all-cause mortality, whereas PLMI was not, though confirmatory studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaf310","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:59:32Z","timestamp":1759406372000},"source":"Crossref","is-referenced-by-count":4,"title":["Respiratory-related leg movement as a predictor of mortality: the Osteoporotic Fractures in Men Sleep Study"],"prefix":"10.1093","volume":"49","author":[{"given":"Neda","family":"Esmaeili","sequence":"first","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School , 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