{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:39:53Z","timestamp":1776364793969,"version":"3.51.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100003305","name":"ResMed Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003305","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ResMed Germany"},{"DOI":"10.13039\/501100005296","name":"University Hospital Regensburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study objectives<\/jats:title>\n                    <jats:p>In patients with acute myocardial infarction (AMI), early use of minute-ventilation triggered adaptive servo-ventilation (ASVmv) for sleep-disordered breathing has been proposed as a therapeutic intervention to reduce infarct expansion. This study aims to assess the efficacy of ASVmv in modulating nocturnal hypoxemic burden and evaluate its association with infarct size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This ancillary analysis of the multicenter, randomized, open-label TEAM-ASV I trial included patients with first-time AMI and sleep-disordered breathing, defined by an apnea-hypopnea index\u2009\u2265\u200915\u00a0events\u00a0h\u22121 assessed with polygraphy. Infarct size was quantified via cardiac magnetic resonance imaging. Nocturnal hypoxemic burden was quantified by the time in bed spent with oxygen saturation below 90% (T90) and further decomposed into desaturation-related components (T90desaturation) and non-specific drifts (T90non-specific).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-five patients with infarct size 15.5\u2009\u00b1\u20096.9% of left ventricular mass were randomized to early ASVmv treatment in addition to standard care of AMI (n\u2009=\u200916) and standard care alone (control, n\u2009=\u200919). Compared with baseline, all components of hypoxemic burden, T90 (9.25% [1.34\u201316.32] vs. 0.03% [0.00\u20131.72; p\u2009=\u2009.003]), T90desaturation (0.72% [0.49\u20137.97] vs. 0.00% [0.00\u20130.06]; p\u2009&amp;lt;\u2009.001), and T90non-specific (4.75% [0.38\u201310.30] vs. 0.00% [0.00\u20131.73]; p\u2009&amp;lt;\u2009.001) were significantly reduced during the ASVmv treatment initiation night. After 12\u00a0weeks, ASVmv treatment showed lower median T90desaturation compared to the control group (ASVmv: 0.10% [0.00\u20130.40] vs. control: 0.40% [0.22\u20131.80]; p\u2009=\u2009.020) but not T90non-specific. T90 (rs\u2009=\u20090.437, p\u2009=\u2009.023) and its component, T90non-specific, were both associated with infarct size (rs\u2009=\u20090.424; p\u2009=\u2009.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ASVmv treatment suppresses the sleep apnea-related nocturnal hypoxemic burden following AMI. Higher T90, particularly non-specific drifts in SpO\u2082, were associated with larger infarct size. These findings are exploratory and should be regarded as hypothesis generating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>NCT02093377.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaf411","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:56:10Z","timestamp":1766494570000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of treatment with minute-ventilation triggered adaptive servo-ventilation early after acute myocardial infarction on nocturnal hypoxemic burden: results from TEAM-ASV I"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4661-1232","authenticated-orcid":false,"given":"Jan","family":"Pec","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Regensburg , Regensburg 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