{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:31Z","timestamp":1792794751651,"version":"4.5.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alterations in sleep\u2013wake patterns are well-recognized features of overt alpha-synucleinopathies. However, their presence in prodromal stages, characterized by isolated Rapid-Eye-Movement (REM) sleep behavior disorder, remains controversial, and their association with clinical symptoms and imaging risk factors has been underexplored. In this study, we used seven-day ambulatory circadian monitoring to characterize circadian and sleep\u2013wake disturbances in a well-characterized sample of forty-two patients with video-polysomnography-confirmed isolated REM sleep behavior disorder and 23 healthy controls. We investigated the associations between circadian disturbances and non-motor clinical symptoms, assessed in a comprehensive neuropsychological protocol, alongside imaging proxies of glymphatic system functioning, namely the Diffusion Tensor Imaging Along the Perivascular Spaces index, and the volume of perivascular spaces and choroid plexuses. Moreover, we assessed the associations between circadian alterations and striatal dopaminergic uptake in the most affected putamen, a well-established risk factor for conversion to alpha-synucleinopathies, as assessed with presynaptic dopaminergic imaging. Patients with isolated REM sleep behavior disorder exhibited reduced diurnal physical activity, along with reduced amplitude and increased fragmentation of the sleep probability and motor activity rhythms. Circadian alterations correlated with greater neuropsychiatric symptoms and reduced psychomotor and mental speed. Patients with isolated REM sleep behavior disorder exhibited a decreased Diffusion Tensor Imaging Along the Perivascular Spaces and larger volume of perivascular spaces, but only the former was associated with sleep impairment. Decreased putaminal dopaminergic uptake was associated with rest-activity rhythm fragmentation. These results show that circadian alterations are observed in early stages of neurodegeneration and are associated with clinical and imaging risk markers of conversion to alpha-synucleinopathies, posing them as possible targets for intervention in prodromal disease stages.<\/jats:p>","DOI":"10.1093\/sleep\/zsaf418","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:31:24Z","timestamp":1767702684000},"source":"Crossref","is-referenced-by-count":4,"title":["Circadian alterations in isolated Rapid-Eye-Movement sleep behavior disorder: associations with clinical, glymphatic, and dopaminergic imaging markers"],"prefix":"10.1093","volume":"49","author":[{"given":"Ignacio","family":"Roura","sequence":"first","affiliation":[{"name":"Medical Psychology Unit, Department of Medicine, University of Barcelona , Barcelona, Catalonia ,","place":["Spain"]},{"name":"Neuropsychology and Neuroimaging Group, Clinical and Experimental Neuroscience Section, Institut 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00edn-Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Medical Psychology Unit, Department of Medicine, University of Barcelona , Barcelona, Catalonia ,","place":["Spain"]},{"name":"Neuropsychology and Neuroimaging Group, Clinical and Experimental Neuroscience Section, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona , Catalonia ,","place":["Spain"]},{"name":"Neuroimaging in Degenerative Disorders group, Experimental Neurology section, Institute of Neurosciences, University of Barcelona , Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6991-8337","authenticated-orcid":false,"given":"Laura","family":"Pacheco-Jaime","sequence":"additional","affiliation":[{"name":"Medical Psychology Unit, Department of Medicine, University of Barcelona , Barcelona, 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