{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T12:06:20Z","timestamp":1784376380952,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hospital Cl\u00ednic Barcelona and Societat Catalana de Pneumologia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Polysomnographic titration of fixed pressures of non-invasive ventilatory support (NIV) is recommended for patients with chronic hypercapnic respiratory failure (CHRF). Here we compared the effects of NIV titrated manually by PSG vs. fully automatic mode (iVAPS AE) in sleep quality, respiratory events manually scored and estimated by built-in software, nocturnal hypoventilation, daytime arterial blood gases and patient comfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 26 adult patients (13 female) with CHRF due to COPD (n\u2009=\u200913), neuromuscular disease (n\u2009=\u20098), obesity hypoventilation syndrome (n\u2009=\u20093) and chest wall disorders (n\u2009=\u20092), all na\u00efve to NIV. They were randomized to standard PSG titration of fixed NIV pressures or PSG using \u201clearn target\u201d iVAPS AE mode in two separate nights, both under PSG monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Main results showed that:(1) there were no significant differences in the reduction of diurnal PaCO2, nocturnal hypoventilation, sleep quality, upper airway obstruction events with both ventilatory modes; (2) the apnea-hypopnea index from built-in software underestimated that manually scored in both ventilatory modes; (3) ventilatory pressures were lower in fixed mode than iVAPS AE mode; (4) patient comfort was higher in fixed mode than iVAPS AE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that iVAPS AE initiated with the \u201clearned target\u201d procedure achieved similar short and long-term ventilatory efficacy to PSG manual bilevel titration. However, its higher pressure levels and lower comfort indicate that the modes are not fully equivalent. Moreover, underestimation of the AHI by the built-in software demands careful interpretation before changing ventilatory settings. Further studies are required to determine the long-term clinical relevance of these differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Information<\/jats:title>\n                    <jats:p>This study was registered at ClinicalTrials.gov under the title \u201cEvaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode\u201d. URL: https:\/\/clinicaltrials.gov\/study\/NCT03872167. Registration number: NCT03872167.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsag085","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:48:28Z","timestamp":1774529308000},"source":"Crossref","is-referenced-by-count":0,"title":["Automatic alveolar ventilation-targeted NIV mode vs polysomnographic titration of fixed pressure in naive patients with chronic respiratory failure"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-0644","authenticated-orcid":false,"given":"M\u00f3nica","family":"Matute-Villac\u00eds","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Hospital Universitari Germans Trias i Pujol , Badalona ,","place":["Spain"]},{"name":"Institut de Recerca Germans Trias i Pujol (IGTP), Badalona ,","place":["Spain"]},{"name":"Universitat de Barcelona (UB) , Barcelona 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Hospital Clinic Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"L\u00f3pez-Escuredo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Respiratory Institute, Hospital Clinic Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Dalmases","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Respiratory Institute, Hospital Clinic Barcelona , Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III , Madrid 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