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Recent clinical trials examining the impact of weight loss on obstructive sleep apnea have demonstrated marked improvements in both weight and obstructive sleep apnea severity, leading to the first Food and Drug Administration approval of a weight loss medication for obstructive sleep apnea. However, several questions remain unanswered regarding which trial and management strategies will best optimize real-world outcomes for patients with comorbid obesity and obstructive sleep apnea in an equitable manner.<\/jats:p>","DOI":"10.1093\/sleep\/zsag116","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:43:06Z","timestamp":1776944586000},"source":"Crossref","is-referenced-by-count":4,"title":["Perspective\u2014weight loss, obstructive sleep apnea therapy, or both for cardiometabolic risk in obesity-related obstructive sleep apnea?"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-7411","authenticated-orcid":false,"given":"Brandon","family":"Nokes","sequence":"first","affiliation":[{"name":"Department of Medicine, Sleep Medicine Section, VA San Diego Healthcare System , San Diego, CA ,","place":["United States"]},{"name":"Department of Medicine, Division of Pulmonary, Critical Care, and Sleep 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