{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:26:51Z","timestamp":1786685211611,"version":"build-2736575974"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurons projecting into the Drosophila dorsal fan-shaped body (dFB) respond electrically during rising sleep pressure to implement sleep. While the molecular and circuit mechanisms that track sleep pressure have been an area of intense focus, less attention has been placed on the downstream neurons targeted by dFB cells to change behavioral state. To identify relevant circuitry, we first used an anterograde transsynaptic labeling tool, trans-Tango, to identify postsynaptic partners of dFB. We found that neurons downstream of dFB resemble h\u0394F cells and through thermogenetic stimulation identify their activity to be wake promoting. We validated these results using independent genetic lines, including highly specific split-Gal4 drivers. Next, we found that h\u0394F neurons express the glutamate transporter VGLUT and the acetylcholine biosynthetic enzyme, Choline acetyltransferase (ChAT). Consistent with their wake promoting role, RNAi-mediated knock down of VGlut and ChAT in h\u0394F increases baseline sleep by sustaining sleep episodes. Furthermore, RNAi for VGlut but not ChAT in h\u2206F cells reduced night-time sleep loss when flies were exposed to night-time light, indicating that these cells promote arousal in response to specific sensory cues. In contrast, VGlut and ChAT knock-down in h\u2206F neurons resulted in enhanced sleep loss while flies were deprived of food overnight. These results suggest that h\u0394F cells may selectively release glutamate and acetylcholine to fine tune arousal responses to changing environmental inputs.<\/jats:p>","DOI":"10.1093\/sleep\/zsag153","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:45:14Z","timestamp":1780487114000},"source":"Crossref","is-referenced-by-count":1,"title":["Context-dependent arousal via wake-promoting pontine neurons in the\n                    <i>Drosophila melanogaster<\/i>\n                    fan-shaped body"],"prefix":"10.1093","volume":"49","author":[{"given":"Abigail","family":"Aleman","sequence":"first","affiliation":[{"name":"Department of Neurobiology, David Geffen School of Medicine, University of California\u2013Los Angeles , Los Angeles, CA ,","place":["United States"]},{"name":"Molecular, Cellular & Integrative Physiology Interdepartmental Program, University of California\u2013Los Angeles , Los Angeles, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-1488","authenticated-orcid":false,"given":"Jeffrey M","family":"Donlea","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, David Geffen School of Medicine, University of California\u2013Los Angeles , Los Angeles, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"1","key":"2026081400274916900_ref1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/sleep\/12.1.13","article-title":"Sleep deprivation in the rat: III. 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