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Award","award":["0094134"],"award-info":[{"award-number":["0094134"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["HORIZON-EIC-2023-PATHFINDERCHALLENGES-01-101\u2009161\u2009509"],"award-info":[{"award-number":["HORIZON-EIC-2023-PATHFINDERCHALLENGES-01-101\u2009161\u2009509"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union or European Innovation Council and SMEs Executive Agency","id":[{"id":"https:\/\/ror.org\/02ex9vk33","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study objectives<\/jats:title>\n                    <jats:p>Sleep duration influences metabolic health, but the impact of daily sleep variation on next-day glycaemia in healthy individuals under real-world conditions is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We studied 206 adolescents (18\u00a0years) from the Copenhagen Prospective Studies on Asthma in Childhood 2000 cohort with 2245 person-days of overlapping accelerometer-derived sleep and continuous glucose monitoring recordings (median 13\u00a0days, IQR 9-13). Sleep duration was assessed using wrist-worn accelerometry, and glycemic concentration, variability, and risk indices were derived from continuous glucose monitoring during the accelerometer-defined waking period. Associations were examined using linear mixed-effects models adjusted for sociodemographic, behavioral, circadian, and cardiometabolic factors, with random effects of individuals across repeated days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Each additional hour of sleep was associated with higher next-day glycaemic concentration (median \u03b2 0.39\u00a0mg\/dL [0.15, 0.63], p\u00a0=\u2009.002), lower variability (standard deviation (SD) mg\/dL \u03b2 \u22120.12 [\u22120.23, \u22120.01], p\u00a0=\u2009.036), and reduced deviation risk (Average Daily Risk Range, indicating lower risk of extreme glucose excursions; \u03b2 \u22120.27 [\u22120.43, \u22120.10], p\u00a0=\u2009.002). Within-person deviations in sleep predicted next-day glycaemic concentration and deviation risk, whereas habitual between-person differences were more strongly associated with variability. Higher daytime glycaemic variability predicted shorter subsequent sleep (\u03b2 \u22120.11\u00a0h [\u22120.18, \u22120.05], p\u00a0&amp;lt;\u20090.001). The early-morning pre-wake glucose rise partly mediated the link between longer sleep and higher next-day median glucose (indirect effect 5.0%, p\u00a0=\u20090.036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate dynamic, bidirectional coupling between sleep and glucose regulation in free-living adolescents, with longer sleep associated with lower next-day glycemic variability and reduced risk of extreme glucose excursions.<\/jats:p>\n                    <jats:p>Statement of Significance Adolescence is a critical period for establishing lifelong sleep and metabolic health patterns, yet real-world links between nightly sleep and glucose regulation remain poorly defined. This study combines accelerometer-derived sleep with continuous glucose monitoring across repeated free-living days in 206 generally healthy adolescents. Wake-anchored analyses showed that longer sleep was associated with modestly higher next-day glycemic concentration, but lower glycemic variability and deviation risk, while greater daytime variability predicted shorter subsequent sleep. A pre-wake glucose rise partly mediated the association between sleep duration and next-day glycemia, suggesting that the transition from sleep to wake may be an important physiological window linking sleep with metabolic regulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsag158","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:37:22Z","timestamp":1781613442000},"source":"Crossref","is-referenced-by-count":0,"title":["Night-to-night sleep duration and wake-anchored glycemia: associations with continuous glucose monitoring in free-living adolescents"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-4561","authenticated-orcid":false,"given":"David","family":"Horner","sequence":"first","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Evensen","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ye","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Section of Food, Microbiology and Fermentation, Department of Food Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jahn","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-8523","authenticated-orcid":false,"given":"Kaare","family":"Tran\u00e6s","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Section of Food, Microbiology and Fermentation, Department of Food Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Thorsen","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Ragnar","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Washington School of Medicine , Seattle, WA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Storoschuk","sequence":"additional","affiliation":[{"name":"Queen\u2019s Muscle Physiology Lab, School of Kinesiology and Health Studies , Queen\u2019s University, Kingston, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-1865","authenticated-orcid":false,"given":"Nanette Mol","family":"Debes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Pediatrics and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannet","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Steno Diabetes Center Copenhagen , Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Merino","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Beck","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Pediatrics and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Jepps","sequence":"additional","affiliation":[{"name":"Vascular Biology Group, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-8544","authenticated-orcid":false,"given":"David S","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen , Herlev ,","place":["Denmark"]},{"name":"New Balance Foundation Obesity Prevention Center, Boston Children\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J F","family":"Loos","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00f8nnelykke","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Vinding","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Pediatrics and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Arendt","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Section of Food, Microbiology and Fermentation, Department of Food Science, University of Copenhagen , Copenhagen 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