{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:02:20Z","timestamp":1789405340759,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Excessive daytime sleepiness is a defining symptom of narcolepsy, affecting daily functioning and quality of life. We developed and evaluated an actigraphy-based nap detection algorithm to objectively estimate daytime naps, a key manifestation of excessive daytime sleepiness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The nap detection algorithm was developed using data from the Multi-Ethnic Study of Atherosclerosis. This dataset included manually annotated naps from 2237 participants with 7\u00a0days of wrist-worn actigraphy. The nap detection algorithm was then applied in studies of participants with narcolepsy type 1 (NT1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our final nap detection algorithm yielded high specificity (Tau B: 93.2%) and accuracy (F1 Area: 83.9%). Applying our algorithm in an observational study (NCT04445129), participants with NT1 experienced 12.8 fewer nap-free days (p\u2009&amp;lt;\u2009.001) over 28\u00a0days and slept 34\u00a0minutes more (p\u2009&amp;lt;\u2009.001) during the day than controls. In a randomized clinical trial (NCT05687903), our algorithm demonstrated that participants with NT1 treated with an orexin receptor 2-selective agonist, oveporexton (TAK-861), experienced 6.1\u221211.9 additional nap-free days and slept 12\u221233\u00a0minutes fewer versus baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, our nap detection algorithm retained sensitivity while minimizing false positives. It reliably identified nap-based phenotypes that differentiate individuals with NT1 from age and sex-matched healthy controls, and it demonstrated that an orexin receptor 2-selective agonist reduces napping in participants with NT1 to normative levels near those of healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsag219","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:21:21Z","timestamp":1786706481000},"source":"Crossref","is-referenced-by-count":0,"title":["An actigraphy-based algorithm to assess daytime napping in people with narcolepsy type 1"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5305-444X","authenticated-orcid":false,"given":"Raul","family":"Torres","sequence":"first","affiliation":[{"name":"Takeda Development Center Americas, Inc. , Cambridge, MA ,","place":["United 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