{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:42Z","timestamp":1790704122215,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"DOI":"10.1093\/sleep\/zsw056","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T10:45:46Z","timestamp":1487155546000},"source":"Crossref","is-referenced-by-count":34,"title":["Antibodies Against Hypocretin Receptor 2 Are Rare in Narcolepsy"],"prefix":"10.1093","volume":"40","author":[{"given":"Maria Pia","family":"Giannoccaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Liguori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,10]]},"reference":[{"issue":"9560","key":"key\n\t\t\t\t20170215045602_CIT0001","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(07)60237-2","article-title":"Narcolepsy with cataplexy","volume":"369","year":"2007","journal-title":"Lancet"},{"issue":"9197","key":"key\n\t\t\t\t20170215045602_CIT0002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0003","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","year":"2000","journal-title":"Neuron"},{"issue":"8","key":"key\n\t\t\t\t20170215045602_CIT0004","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/sleep\/32.8.993","article-title":"Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy","volume":"32","year":"2009","journal-title":"Sleep"},{"issue":"8800","key":"key\n\t\t\t\t20170215045602_CIT0005","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(92)90571-J","article-title":"DQ (rather than DR) gene marks susceptibility to narcolepsy","volume":"339","year":"1992","journal-title":"Lancet"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0006","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","year":"2001","journal-title":"Am J Hum Genet"},{"issue":"5","key":"key\n\t\t\t\t20170215045602_CIT0007","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.conb.2013.04.013","article-title":"The autoimmune basis of narcolepsy","volume":"23","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"key\n\t\t\t\t20170215045602_CIT0008","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014","edition":"3rd"},{"issue":"9","key":"key\n\t\t\t\t20170215045602_CIT0009","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.5665\/sleep.2080","article-title":"Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy","volume":"35","year":"2012","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170215045602_CIT0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-5728(01)00333-2","article-title":"Narcolepsy and the HLA region","volume":"117","year":"2001","journal-title":"J Neuroimmunol"},{"issue":"8","key":"key\n\t\t\t\t20170215045602_CIT0011","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","year":"2009","journal-title":"Sleep"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0012","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","year":"2011","journal-title":"Ann Neurol"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0013","doi-asserted-by":"crossref","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"key\n\t\t\t\t20170215045602_CIT0014","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/WNR.0b013e328010baad","article-title":"Antibodies in narcolepsy-cataplexy patient serum bind to rat hypocretin neurons","volume":"18","year":"2007","journal-title":"Neuroreport"},{"issue":"1","key":"key\n\t\t\t\t20170215045602_CIT0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/sleep\/30.1.27","article-title":"Evaluation of hypothalamic-specific autoimmunity in patients with narcolepsy","volume":"30","year":"2007","journal-title":"Sleep"},{"issue":"4","key":"key\n\t\t\t\t20170215045602_CIT0016","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/sleep\/28.4.427","article-title":"Analysis of hypocretin (orexin) antibodies in patients with narcolepsy","volume":"28","year":"2005","journal-title":"Sleep"},{"issue":"5","key":"key\n\t\t\t\t20170215045602_CIT0017","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/sleep\/29.5.633","article-title":"Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy","volume":"29","year":"2006","journal-title":"Sleep"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0018","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1172\/JCI41366","article-title":"Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"issue":"6","key":"key\n\t\t\t\t20170215045602_CIT0019","doi-asserted-by":"crossref","first-page":"e0129555","DOI":"10.1371\/journal.pone.0129555","article-title":"Neuronal Antibodies in Children with or without Narcolepsy following H1N1-AS03 Vaccination","volume":"10","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"key\n\t\t\t\t20170215045602_CIT0020","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/sleep\/25.7.719","article-title":"Search for neuron-specific and non neuron-specific antibodies in narcoleptic patients with and without HLA DQB1*0602","volume":"25","year":"2002","journal-title":"Sleep"},{"issue":"294","key":"key\n\t\t\t\t20170215045602_CIT0021","doi-asserted-by":"crossref","first-page":"294ra105","DOI":"10.1126\/scitranslmed.aab2354","article-title":"Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2","volume":"7","year":"2015","journal-title":"Sci Transl Med"},{"issue":"314","key":"key\n\t\t\t\t20170215045602_CIT0022","doi-asserted-by":"crossref","first-page":"314le2","DOI":"10.1126\/scitranslmed.aad2353","article-title":"Comment on \u201cAntibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2\u201d","volume":"7","year":"2015","journal-title":"Sci Transl Med"},{"issue":"4","key":"key\n\t\t\t\t20170215045602_CIT0023","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","article-title":"A clinical approach to diagnosis of autoimmune encephalitis","volume":"15","year":"2016","journal-title":"Lancet Neurol"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0024","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1212\/NXI.0000000000000089","article-title":"MOG cell-based assay detects non-MS patients with inflammatory neurologic disease","volume":"2","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"7","key":"key\n\t\t\t\t20170215045602_CIT0025","first-page":"1940","article-title":"IgG1 antibodies to acetylcholine receptors in seronegative myasthenia gravis","volume":"131","year":"2008"},{"issue":"10","key":"key\n\t\t\t\t20170215045602_CIT0026","first-page":"1305","article-title":"Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy","volume":"70","year":"2013","journal-title":"JAMA Neurol"},{"issue":"4","key":"key\n\t\t\t\t20170215045602_CIT0027","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.smrv.2005.03.004","article-title":"Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin\/orexin system","volume":"9","year":"2005","journal-title":"Sleep Med Rev"},{"issue":"38","key":"key\n\t\t\t\t20170215045602_CIT0028","doi-asserted-by":"crossref","first-page":"12642","DOI":"10.1523\/JNEUROSCI.2120-10.2010","article-title":"Orexin directly excites orexin neurons through orexin 2 receptor","volume":"30","year":"2010","journal-title":"J Neurosci"},{"issue":"11","key":"key\n\t\t\t\t20170215045602_CIT0029","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrn3837","article-title":"The role of orexin in motivated behaviours","volume":"15","year":"2014","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"key\n\t\t\t\t20170215045602_CIT0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1750-3639.2003.tb00033.x","article-title":"Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy","volume":"13","year":"2003","journal-title":"Brain Pathol"}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/40\/2\/zsw056\/10372696\/zsw056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:57:02Z","timestamp":1692687422000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/2666711\/Antibodies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,10]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,12,10]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsw056","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,10]]}}}