{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:49Z","timestamp":1792794769355,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Swiss National Science Foundation, Lung League of Zurich","id":[{"id":"https:\/\/ror.org\/00yjd3n13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/sleep\/zsy203","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T01:43:56Z","timestamp":1543887836000},"source":"Crossref","is-referenced-by-count":36,"title":["Sleep and breathing disturbances in patients with chronic obstructive pulmonary disease traveling to altitude: a randomized trial"],"prefix":"10.1093","volume":"42","author":[{"given":"Tsogyal D","family":"Latshang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 P M","family":"Tardent","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furian","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Flueck","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian D","family":"Segitz","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Mueller-Mottet","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"key\n\t\t\t\t2019011707282754300_CIT0001","author":"Tourism in Mountain Regions","year":"2014"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0002","unstructured":"Tourism Statistics \u2013 Intra-EU Tourism Flows. 2017. http:\/\/ec.europa.eu\/eurostat\/statistics-explained\/index.php\/Tourism_statistics_-_intra-EU_tourism_flows. Accessed February 20, 2018."},{"issue":"6","key":"key\n\t\t\t\t2019011707282754300_CIT0003","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1152\/japplphysiol.00186.2017","article-title":"Effect of hypoxia and hyperoxia on exercise performance in healthy individuals and in patients with pulmonary hypertension: a systematic review","volume":"123","author":"Ulrich","year":"2017","journal-title":"J Appl Physiol (1985)"},{"issue":"12","key":"key\n\t\t\t\t2019011707282754300_CIT0004","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1152\/japplphysiol.00448.2015","article-title":"Sleep at high altitude: guesses and facts","volume":"119","author":"Bloch","year":"2015","journal-title":"J Appl Physiol (1985)"},{"issue":"24","key":"key\n\t\t\t\t2019011707282754300_CIT0005","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMcp1214870","article-title":"Clinical practice: acute high-altitude illnesses","volume":"368","author":"B\u00e4rtsch","year":"2013","journal-title":"N Engl J Med"},{"issue":"12","key":"key\n\t\t\t\t2019011707282754300_CIT0006","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.5665\/sleep.3242","article-title":"Are nocturnal breathing, sleep, and cognitive performance impaired at moderate altitude (1,630-2,590 m)","volume":"36","author":"Latshang","year":"2013","journal-title":"Sleep"},{"issue":"3","key":"key\n\t\t\t\t2019011707282754300_CIT0007","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5665\/sleep.1708","article-title":"Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing","volume":"35","author":"Nussbaumer-Ochsner","year":"2012","journal-title":"Sleep"},{"issue":"4","key":"key\n\t\t\t\t2019011707282754300_CIT0008","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1164\/rccm.200911-1694OC","article-title":"Nocturnal periodic breathing during acclimatization at very high altitude at Mount Muztagh Ata (7,546 m)","volume":"182","author":"Bloch","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0009","unstructured":"Global Strategy for Diagnosis, Management, and Prevention of COPD \u2013 2017. 2017. http:\/\/goldcopd.org\/gold-2017-global-strategy-diagnosis-management-prevention-copd\/. Accessed February 20, 2018."},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0010","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000258676","article-title":"Sleep and sleep disorders in chronic obstructive pulmonary disease","volume":"80","author":"Collop","year":"2010","journal-title":"Respiration"},{"issue":"7","key":"key\n\t\t\t\t2019011707282754300_CIT0011","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1440-1843.2012.02217.x","article-title":"Sleep quality in chronic obstructive pulmonary disease","volume":"17","author":"McSharry","year":"2012","journal-title":"Respirology"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0012","doi-asserted-by":"crossref","first-page":"7947198","DOI":"10.1155\/2016\/7947198","article-title":"Sleep in chronic obstructive pulmonary disease: evidence gaps and challenges","volume":"2016","author":"Jen","year":"2016","journal-title":"Can Respir J"},{"issue":"6","key":"key\n\t\t\t\t2019011707282754300_CIT0013","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000486450","article-title":"Exercise performance of lowlanders with COPD at 2,590 m: data from a randomized trial","volume":"95","author":"Furian","year":"2018","journal-title":"Respiration"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0014","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/COPD.S173039","article-title":"Exercise performance and symptoms in lowlanders with COPD ascending to moderate altitude: randomized trial","volume":"13","author":"Furian","year":"2018","journal-title":"Int J Chron Obstr Pulmon Dis"},{"issue":"22","key":"key\n\t\t\t\t2019011707282754300_CIT0015","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1001\/jama.2012.94847","article-title":"Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial","volume":"308","author":"Latshang","year":"2012","journal-title":"JAMA"},{"issue":"3","key":"key\n\t\t\t\t2019011707282754300_CIT0016","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1183\/09031936.97.10030576","article-title":"Breathing pattern during sleep disruptive snoring","volume":"10","author":"Bloch","year":"1997","journal-title":"Eur Respir J"},{"issue":"6","key":"key\n\t\t\t\t2019011707282754300_CIT0017","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1152\/jappl.2000.88.6.1955","article-title":"Respiratory muscle activity measured with a noninvasive EMG technique: technical aspects and reproducibility","volume":"88","author":"Maarsingh","year":"2000","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"key\n\t\t\t\t2019011707282754300_CIT0018","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1378\/chest.128.3.1291","article-title":"Monitoring carbon dioxide tension and arterial oxygen saturation by a single earlobe sensor in patients with critical illness or sleep apnea","volume":"128","author":"Senn","year":"2005","journal-title":"Chest"},{"issue":"10 Pt 1","key":"key\n\t\t\t\t2019011707282754300_CIT0019","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1164\/ajrccm.164.10.2102104","article-title":"Accuracy of nasal cannula pressure recordings for assessment of ventilation during sleep","volume":"164","author":"Thurnheer","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0020","volume-title":"A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects","author":"Rechtschaffen","year":"1968"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0021","first-page":"174","author":"Sleep Disorders Atlas Task Force of the American Sleep Disorders Association","year":"1992"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0022","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research","volume":"22","author":"American Academy of Sleep Medicine Task Force","year":"1999","journal-title":"Sleep"},{"issue":"5","key":"key\n\t\t\t\t2019011707282754300_CIT0023","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.2009.125849","article-title":"Exacerbation of sleep apnoea by frequent central events in patients with the obstructive sleep apnoea syndrome at altitude: a randomised trial","volume":"65","author":"Nussbaumer-Ochsner","year":"2010","journal-title":"Thorax"},{"issue":"7","key":"key\n\t\t\t\t2019011707282754300_CIT0024","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.clinph.2006.03.011","article-title":"Validation of the Karolinska sleepiness scale against performance and EEG variables","volume":"117","author":"Kaida","year":"2006","journal-title":"Clin Neurophysiol"},{"issue":"12 Pt 1","key":"key\n\t\t\t\t2019011707282754300_CIT0025","first-page":"1063","article-title":"Procedures for the measurement of acute mountain sickness","volume":"54","author":"Sampson","year":"1983","journal-title":"Aviat Space Environ Med"},{"issue":"5","key":"key\n\t\t\t\t2019011707282754300_CIT0026","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/sleep\/34.5.581","article-title":"Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss","volume":"34","author":"Basner","year":"2011","journal-title":"Sleep"},{"issue":"2","key":"key\n\t\t\t\t2019011707282754300_CIT0027","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","article-title":"Trail making test A and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch Clin Neuropsychol"},{"issue":"6","key":"key\n\t\t\t\t2019011707282754300_CIT0028","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000368615","article-title":"Predictors of the overlap syndrome and its association with comorbidities in patients with chronic obstructive pulmonary disease","volume":"88","author":"Steveling","year":"2014","journal-title":"Respiration"},{"issue":"8","key":"key\n\t\t\t\t2019011707282754300_CIT0029","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1513\/AnnalsATS.201407-336OC","article-title":"High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease","volume":"12","author":"Soler","year":"2015","journal-title":"Ann Am Thorac Soc"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1164\/rccm.2203046","article-title":"Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease","volume":"167","author":"Sanders","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"key\n\t\t\t\t2019011707282754300_CIT0031","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0032","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1183\/09031936.00119807","article-title":"Children at high altitude have less nocturnal periodic breathing than adults","volume":"32","author":"Kohler","year":"2008","journal-title":"Eur Respir J"},{"issue":"2","key":"key\n\t\t\t\t2019011707282754300_CIT0033","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1164\/rccm.201402-0302LE","article-title":"Neural respiratory drive and ventilation in patients with chronic obstructive pulmonary disease during sleep","volume":"190","author":"Luo","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"key\n\t\t\t\t2019011707282754300_CIT0034","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/thoraxjnl-2016-208467","article-title":"Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD","volume":"72","author":"He","year":"2017","journal-title":"Thorax"},{"issue":"5","key":"key\n\t\t\t\t2019011707282754300_CIT0035","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1378\/chest.115.5.1293","article-title":"Ventilatory drive at rest and perception of exertional dyspnea in severe COPD","volume":"115","author":"Marin","year":"1999","journal-title":"Chest"},{"issue":"10","key":"key\n\t\t\t\t2019011707282754300_CIT0036","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1164\/rccm.201704-0675OC","article-title":"Excess ventilation in chronic obstructive pulmonary disease-heart failure overlap. Implications for dyspnea and exercise intolerance","volume":"196","author":"Rocha","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"key\n\t\t\t\t2019011707282754300_CIT0037","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/eurjhf\/hfp057","article-title":"Sleep-disordered breathing in heart failure with normal left ventricular ejection fraction","volume":"11","author":"Bitter","year":"2009","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0038","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"Dempsey","year":"2010","journal-title":"Physiol Rev"},{"issue":"4","key":"key\n\t\t\t\t2019011707282754300_CIT0039","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.sleep.2010.08.017","article-title":"Sleep profile and symptoms of sleep disorders in patients with stable mild to moderate chronic obstructive pulmonary disease","volume":"12","author":"Valipour","year":"2011","journal-title":"Sleep Med"},{"issue":"8","key":"key\n\t\t\t\t2019011707282754300_CIT0040","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/thoraxjnl-2016-208900","article-title":"Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity","volume":"72","author":"Spina","year":"2017","journal-title":"Thorax"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0041","first-page":"76","article-title":"Are sleep, nocturnal breathing and daytime performance impaired at moderate altitude","volume":"82","author":"Latshang","year":"2011","journal-title":"Respiration"},{"issue":"10","key":"key\n\t\t\t\t2019011707282754300_CIT0042","doi-asserted-by":"crossref","first-page":"e76945","DOI":"10.1371\/journal.pone.0076945","article-title":"Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)","volume":"8","author":"Stadelmann","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0043","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuint.2010.11.003","article-title":"Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture","volume":"58","author":"Ray","year":"2011","journal-title":"Neurochem Int"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0044","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0034-5687(95)00057-7","article-title":"Dynamics of periodic breathing and arousal during sleep at extreme altitude","volume":"103","author":"Khoo","year":"1996","journal-title":"Respir Physiol"},{"issue":"1","key":"key\n\t\t\t\t2019011707282754300_CIT0045","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1469-8986.2003.00130.x","article-title":"Awareness of sleepiness when driving","volume":"41","author":"Horne","year":"2004","journal-title":"Psychophysiology"},{"issue":"4","key":"key\n\t\t\t\t2019011707282754300_CIT0046","first-page":"267","article-title":"Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night","volume":"20","author":"Dinges","year":"1997","journal-title":"Sleep"},{"key":"key\n\t\t\t\t2019011707282754300_CIT0047","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/bmj.289.6449.878","article-title":"Nocturnal deaths among patients with chronic bronchitis and emphysema","volume":"289","author":"McNicholas","year":"1984","journal-title":"Br Med J (Clin Res Ed)"}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/42\/1\/zsy203\/27511074\/zsy203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:40:28Z","timestamp":1775292028000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsy203\/5229280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,4]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsy203","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,12,4]]}}}