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The pathophysiological mechanisms of IH remain unclear. Because of the involvement of the default-mode network (DMN) in alertness and sleep, our aim was to investigate the structural and functional modifications of the DMN in IH. We conducted multimodal magnetic resonance imaging (MRI) in 12 participants with IH and 15 good sleeper controls (mean age \u00b1 SD: 32 \u00b1 9.6 years, range 22\u201353 years, nine males). Self-reported as well as objective measures of daytime sleepiness were collected. Gray matter volume and cortical thickness were analyzed to investigate brain structural differences between good sleepers and IH. Structural covariance and resting-state functional connectivity were analyzed to investigate changes in the DMN. Participants with IH had greater volume and cortical thickness in the precuneus, a posterior hub of the DMN. Cortical thickness in the left medial prefrontal cortex was positively correlated with thickness of the precuneus, and the strength of this correlation was greater in IH. In contrast, functional connectivity at rest was lower within the anterior DMN (medial prefrontal cortex) in IH, and correlated with self-reported daytime sleepiness. The present results show that IH is associated with structural and functional differences in the DMN, in proportion to the severity of daytime sleepiness, suggesting that a disruption of the DMN contributes to the clinical features of IH. Larger volume and thickness in this network might reflect compensatory changes to lower functional connectivity in IH.<\/jats:p>","DOI":"10.1093\/sleep\/zsz156","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T11:59:55Z","timestamp":1563796795000},"source":"Crossref","is-referenced-by-count":39,"title":["Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-9825","authenticated-orcid":false,"given":"Florence B","family":"Pomares","sequence":"first","affiliation":[{"name":"Center for Studies in Behavioral Neurobiology and Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada"},{"name":"PERFORM Centre, Concordia University, Montreal, QC, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"Boucetta","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Lachapelle","sequence":"additional","affiliation":[{"name":"Center for Studies in Behavioral Neurobiology and Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada"},{"name":"PERFORM Centre, Concordia University, Montreal, QC, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Steffener","sequence":"additional","affiliation":[{"name":"Interdisciplinary School of Health Science, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Montplaisir","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montreal, QC, Canada"},{"name":"Department of Psychiatry, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-2051","authenticated-orcid":false,"given":"Jungho","family":"Cha","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosung","family":"Kim","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 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