{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:45:13Z","timestamp":1790779513266,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Amway"},{"DOI":"10.13039\/100012515","name":"Cyrus Tang Foundation","doi-asserted-by":"publisher","award":["419600-11102"],"award-info":[{"award-number":["419600-11102"]}],"id":[{"id":"10.13039\/100012515","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang University Education Foundation"},{"name":"Zhejiang Province Key laboratory Fund of China","award":["2011E10006"],"award-info":[{"award-number":["2011E10006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Study Objectives<\/jats:title><jats:p>To investigate the relationship between dry eye and sleep quality in a large community-based Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3,070 participants aged 18\u201380 were recruited from a community-based study in Hangzhou, China during 2016\u20132017. Sleep quality was evaluated using the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI), and dry eye was evaluated using the Ocular Surface Disease Index (OSDI) questionnaire. Multivariable linear regression and logistic regression models were used to investigate the associations, adjusting for age, smoking, drinking, season, and other potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, CPSQI score and sleep dysfunction were significantly associated with mild, moderate, and severe dry eye (ORs for CPSQI score: 1.07, 1.13, 1.14, all p &lt; 0.001; for sleep dysfunction: 1.31, 1.73, 1.66, all p &lt; 0.05). Furthermore, worse OSDI score was presented in participants with worse CPSQI score or sleep dysfunction (CPSQI score &gt; 7) (\u03b2: 0.13, 0.54; all p &lt; 0.001). In addition, six of the seven components of CPSQI showed significant associations with dry eye (all p &lt; 0.001), except for the component of sleep medication use. Moreover, we observed significant associations of dry eye in all three subscales of OSDI with CPSQI score and sleep dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our large, community-based study showed a strong association between poor sleep quality and an increased severity of dry eye, suggesting that preventing either one of the discomforts might alleviate the other.<\/jats:p><\/jats:sec>","DOI":"10.1093\/sleep\/zsz160","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T13:26:03Z","timestamp":1563283563000},"source":"Crossref","is-referenced-by-count":51,"title":["Dry eye and sleep quality: a large community-based study in Hangzhou"],"prefix":"10.1093","volume":"42","author":[{"given":"Xiaoning","family":"Yu","sequence":"first","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Chronic Disease Research Institute, School of 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Public Health, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-3511","authenticated-orcid":false,"given":"Ann","family":"Hsing","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-7364","authenticated-orcid":false,"given":"Shankuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Women\u2019s 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