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This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta\u2013gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta\u2013gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta\u2013gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e. cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.<\/jats:p>","DOI":"10.1093\/sleep\/zsz182","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T22:14:25Z","timestamp":1565820865000},"source":"Crossref","is-referenced-by-count":64,"title":["Dynamic modulation of theta\u2013gamma coupling during rapid eye movement sleep"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-1374","authenticated-orcid":false,"given":"Mojtaba","family":"Bandarabadi","sequence":"first","affiliation":[{"name":"Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department for BioMedical Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Boyce","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Gutierrez Herrera","sequence":"additional","affiliation":[{"name":"Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department for BioMedical Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio L","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department for BioMedical Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Schindler","sequence":"additional","affiliation":[{"name":"Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department for BioMedical Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-5175","authenticated-orcid":false,"given":"Antoine","family":"Adamantidis","sequence":"additional","affiliation":[{"name":"Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department for BioMedical Research, University of 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