{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:15Z","timestamp":1792144095916,"version":"4.4.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Narcolepsy with cataplexy is a sleep disorder caused by a deficiency in hypocretin neurons in the lateral hypothalamus (LH). Here we performed an epigenome-wide association study (EWAS) of DNA methylation for narcolepsy and replication analyses using DNA samples extracted from two brain regions: LH (Cases: N = 4; Controls: N = 4) and temporal cortex (Cases: N = 7; Controls: N = 7). Seventy-seven differentially methylated regions (DMRs) were identified in the LH analysis, with the top association of a DMR in the myelin basic protein (MBP) region. Only five DMRs were detected in the temporal cortex analysis. Genes annotated to LH DMRs were significantly associated with pathways related to fatty acid response or metabolism. Two additional analyses applying the EWAS data were performed: (1) investigation of methylation profiles shared between narcolepsy and other disorders and (2) an integrative analysis of DNA methylation data and a genome-wide association study for narcolepsy. The results of the two approaches, which included significant overlap of methylated positions associated with narcolepsy and multiple sclerosis, indicated that the two diseases may partly share their pathogenesis. In conclusion, DNA methylation in LH where loss of orexin-producing neurons occurs may play a role in the pathophysiology of the disease.<\/jats:p>","DOI":"10.1093\/sleep\/zsz198","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T01:23:30Z","timestamp":1569547410000},"source":"Crossref","is-referenced-by-count":17,"title":["Epigenome-wide association study of narcolepsy-affected lateral hypothalamic brains, and overlapping DNA methylation profiles between narcolepsy and multiple sclerosis"],"prefix":"10.1093","volume":"43","author":[{"given":"Mihoko","family":"Shimada","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"},{"name":"Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"},{"name":"Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Niizato","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"},{"name":"Seiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"2020011304204386600_CIT0001","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1212\/WNL.50.2_Suppl_1.S16","article-title":"Genetic and familial aspects of narcolepsy","volume":"50","author":"Mignot","year":"1998","journal-title":"Neurology."},{"issue":"2","key":"2020011304204386600_CIT0002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/sleep\/25.2.197","article-title":"The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study","volume":"25","author":"Silber","year":"2002","journal-title":"Sleep."},{"issue":"9416","key":"2020011304204386600_CIT0003","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(04)15951-5","article-title":"Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway","volume":"363","author":"Khatami","year":"2004","journal-title":"Lancet."},{"issue":"9","key":"2020011304204386600_CIT0004","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat Med."},{"issue":"3","key":"2020011304204386600_CIT0005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"issue":"5","key":"2020011304204386600_CIT0006","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1399-0039.1984.tb02144.x","article-title":"HLA antigens in Japanese patients with narcolepsy. all the patients were DR2 positive","volume":"24","author":"Juji","year":"1984","journal-title":"Tissue Antigens"},{"issue":"3","key":"2020011304204386600_CIT0007","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","author":"Mignot","year":"2001","journal-title":"Am J Hum Genet."},{"issue":"1","key":"2020011304204386600_CIT0008","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ajhg.2014.12.010","article-title":"HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy","volume":"96","author":"Ollila","year":"2015","journal-title":"Am J Hum Genet."},{"issue":"3","key":"2020011304204386600_CIT0009","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/hmg\/ddu480","article-title":"New susceptibility variants to narcolepsy identified in HLA class II region","volume":"24","author":"Miyagawa","year":"2015","journal-title":"Hum Mol Genet."},{"issue":"6","key":"2020011304204386600_CIT0010","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat Genet."},{"issue":"2","key":"2020011304204386600_CIT0011","doi-asserted-by":"crossref","first-page":"e1003270","DOI":"10.1371\/journal.pgen.1003270","article-title":"ImmunoChip study implicates antigen presentation to T cells in narcolepsy","volume":"9","author":"Faraco","year":"2013","journal-title":"PLoS Genet."},{"issue":"10","key":"2020011304204386600_CIT0012","doi-asserted-by":"crossref","first-page":"e1003880","DOI":"10.1371\/journal.pgen.1003880","article-title":"Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic","volume":"9","author":"Han","year":"2013","journal-title":"PLoS Genet."},{"issue":"1","key":"2020011304204386600_CIT0013","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng.734","article-title":"Common variants in P2RY11 are associated with narcolepsy","volume":"43","author":"Kornum","year":"2011","journal-title":"Nat Genet."},{"key":"2020011304204386600_CIT0014","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbi.2015.05.003","article-title":"A polymorphism in CCR1\/CCR3 is associated with narcolepsy","volume":"49","author":"Toyoda","year":"2015","journal-title":"Brain Behav Immun."},{"issue":"11","key":"2020011304204386600_CIT0015","doi-asserted-by":"crossref","first-page":"e0187888","DOI":"10.1371\/journal.pone.0187888","article-title":"Narcolepsy susceptibility gene CCR3 modulates sleep-wake patterns in mice","volume":"12","author":"Toyoda","year":"2017","journal-title":"PLoS One."},{"issue":"11","key":"2020011304204386600_CIT0016","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ng.231","article-title":"Variant between CPT1B and CHKB associated with susceptibility to narcolepsy","volume":"40","author":"Miyagawa","year":"2008","journal-title":"Nat Genet."},{"issue":"6409","key":"2020011304204386600_CIT0017","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.aat6806","article-title":"Dynamic DNA methylation: in the right place at the right time","volume":"361","author":"Luo","year":"2018","journal-title":"Science."},{"issue":"10","key":"2020011304204386600_CIT0018","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/nbt.1685","article-title":"Epigenetic modifications and human disease","volume":"28","author":"Portela","year":"2010","journal-title":"Nat Biotechnol."},{"issue":"8","key":"2020011304204386600_CIT0019","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"issue":"3","key":"2020011304204386600_CIT0020","doi-asserted-by":"crossref","first-page":"e33536","DOI":"10.1371\/journal.pone.0033536","article-title":"AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland","volume":"7","author":"Nohynek","year":"2012","journal-title":"PLoS One."},{"issue":"4","key":"2020011304204386600_CIT0021","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy019","article-title":"An epigenome-wide association study of DNA methylation and an integrated genetic and epigenetic approach for narcolepsy","volume":"41","author":"Shimada","year":"2018","journal-title":"Sleep"},{"issue":"7559","key":"2020011304204386600_CIT0022","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature14465","article-title":"Human body epigenome maps reveal noncanonical DNA methylation variation","volume":"523","author":"Schultz","year":"2015","journal-title":"Nature."},{"key":"2020011304204386600_CIT0023","volume-title":"The International Classification of Sleep Disorders: Diagnostic and Coding Manual","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"2020011304204386600_CIT0024","volume-title":"Atlas of the Human Brain","author":"Mai","year":"1997"},{"issue":"3","key":"2020011304204386600_CIT0025","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/bioinformatics\/btt684","article-title":"ChAMP: 450k chip analysis methylation pipeline","volume":"30","author":"Morris","year":"2014","journal-title":"Bioinformatics."},{"issue":"4","key":"2020011304204386600_CIT0026","first-page":"e22","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"7319","key":"2020011304204386600_CIT0027","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Abecasis","year":"2010","journal-title":"Nature."},{"issue":"7571","key":"2020011304204386600_CIT0028","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature."},{"issue":"2","key":"2020011304204386600_CIT0029","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","article-title":"A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data","volume":"29","author":"Teschendorff","year":"2013","journal-title":"Bioinformatics."},{"issue":"1","key":"2020011304204386600_CIT0030","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics."},{"key":"2020011304204386600_CIT0031","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinformatics."},{"key":"2020011304204386600_CIT0032","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13148-017-0333-7","article-title":"Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours","volume":"9","author":"Kling","year":"2017","journal-title":"Clin Epigenetics."},{"issue":"10","key":"2020011304204386600_CIT0033","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"issue":"1","key":"2020011304204386600_CIT0034","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13059-017-1182-6","article-title":"MeDeCom: discovery and quantification of latent components of heterogeneous methylomes","volume":"18","author":"Lutsik","year":"2017","journal-title":"Genome Biol."},{"issue":"1","key":"2020011304204386600_CIT0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ije\/dyr238","article-title":"Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies","volume":"41","author":"Jaffe","year":"2012","journal-title":"Int J Epidemiol."},{"issue":"10","key":"2020011304204386600_CIT0036","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4161\/epi.25865","article-title":"Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes","volume":"8","author":"Masliah","year":"2013","journal-title":"Epigenetics."},{"issue":"9","key":"2020011304204386600_CIT0037","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer\u2019s disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat Neurosci."},{"issue":"1","key":"2020011304204386600_CIT0038","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nn.3588","article-title":"Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains","volume":"17","author":"Huynh","year":"2014","journal-title":"Nat Neurosci."},{"key":"2020011304204386600_CIT0039","doi-asserted-by":"crossref","first-page":"e433","DOI":"10.1038\/tp.2014.70","article-title":"DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways","volume":"4","author":"Nardone","year":"2014","journal-title":"Transl Psychiatry."},{"issue":"1","key":"2020011304204386600_CIT0040","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nn.4181","article-title":"Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex","volume":"19","author":"Jaffe","year":"2016","journal-title":"Nat Neurosci."},{"issue":"6","key":"2020011304204386600_CIT0041","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet."},{"key":"2020011304204386600_CIT0042","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience."},{"issue":"1","key":"2020011304204386600_CIT0043","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet."},{"issue":"2","key":"2020011304204386600_CIT0044","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"issue":"1","key":"2020011304204386600_CIT0045","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajhg.2015.05.018","article-title":"A powerful pathway-based adaptive test for genetic association with common or rare variants","volume":"97","author":"Pan","year":"2015","journal-title":"Am J Hum Genet."},{"issue":"3","key":"2020011304204386600_CIT0046","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1101\/gr.147942.112","article-title":"Dynamic DNA methylation across diverse human cell lines and tissues","volume":"23","author":"Varley","year":"2013","journal-title":"Genome Res."},{"issue":"7463","key":"2020011304204386600_CIT0047","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature12433","article-title":"Charting a dynamic DNA methylation landscape of the human genome","volume":"500","author":"Ziller","year":"2013","journal-title":"Nature."},{"issue":"4","key":"2020011304204386600_CIT0048","doi-asserted-by":"crossref","first-page":"e5394","DOI":"10.1371\/journal.pone.0005394","article-title":"Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia)","volume":"4","author":"Miyagawa","year":"2009","journal-title":"PLoS One."},{"issue":"3","key":"2020011304204386600_CIT0049","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/sleep\/34.3.349","article-title":"Abnormally low serum acylcarnitine levels in narcolepsy patients","volume":"34","author":"Miyagawa","year":"2011","journal-title":"Sleep."},{"issue":"1","key":"2020011304204386600_CIT0050","doi-asserted-by":"crossref","first-page":"e53707","DOI":"10.1371\/journal.pone.0053707","article-title":"Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial","volume":"8","author":"Miyagawa","year":"2013","journal-title":"PLoS One."},{"issue":"1","key":"2020011304204386600_CIT0051","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13072-018-0225-x","article-title":"Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs","volume":"11","author":"van Dongen","year":"2018","journal-title":"Epigenetics Chromatin."},{"issue":"3","key":"2020011304204386600_CIT0052","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4161\/epi.23924","article-title":"A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression","volume":"8","author":"Guintivano","year":"2013","journal-title":"Epigenetics."},{"issue":"12","key":"2020011304204386600_CIT0053","doi-asserted-by":"crossref","first-page":"3334.e7","DOI":"10.1016\/j.neurobiolaging.2015.08.028","article-title":"DNA methylation levels of \u03b1-synuclein intron 1 in the aging brain","volume":"36","author":"de Boni","year":"2015","journal-title":"Neurobiol Aging."},{"issue":"3","key":"2020011304204386600_CIT0054","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jnc.12195","article-title":"Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms","volume":"125","author":"Harauz","year":"2013","journal-title":"J Neurochem."},{"issue":"1","key":"2020011304204386600_CIT0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20150710","article-title":"MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis","volume":"472","author":"Vassall","year":"2015","journal-title":"Biochem J"},{"issue":"8","key":"2020011304204386600_CIT0056","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/glia.22520","article-title":"Molecular evolution of myelin basic protein, an abundant structural myelin component","volume":"61","author":"Nawaz","year":"2013","journal-title":"Glia."},{"key":"2020011304204386600_CIT0057","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1038\/tp.2014.107","article-title":"Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT-deficient mice","volume":"4","author":"Schraut","year":"2014","journal-title":"Transl Psychiatry."},{"issue":"9648","key":"2020011304204386600_CIT0058","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"issue":"10","key":"2020011304204386600_CIT0059","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ng.3395","article-title":"Class II HLA interactions modulate genetic risk for multiple sclerosis","volume":"47","author":"Moutsianas","year":"2015","journal-title":"Nat Genet"},{"issue":"4","key":"2020011304204386600_CIT0060","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1212\/NXI.0000000000000249","article-title":"Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis","volume":"3","author":"Jennum","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm."},{"issue":"9","key":"2020011304204386600_CIT0061","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.3390\/ijms130911718","article-title":"Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms","volume":"13","author":"O\u2019Gorman","year":"2012","journal-title":"Int J Mol Sci."},{"issue":"33","key":"2020011304204386600_CIT0062","doi-asserted-by":"crossref","first-page":"55265","DOI":"10.18632\/oncotarget.19423","article-title":"Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection","volume":"8","author":"Funata","year":"2017","journal-title":"Oncotarget."},{"issue":"1","key":"2020011304204386600_CIT0063","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1038\/s41598-017-08370-7","article-title":"Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus","volume":"7","author":"Okabe","year":"2017","journal-title":"Sci Rep."},{"issue":"4","key":"2020011304204386600_CIT0064","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/path.4909","article-title":"Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells","volume":"242","author":"Matsusaka","year":"2017","journal-title":"J Pathol."},{"issue":"1","key":"2020011304204386600_CIT0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1074\/jbc.M405973200","article-title":"Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation","volume":"280","author":"Lu","year":"2005","journal-title":"J Biol Chem"},{"key":"2020011304204386600_CIT0066","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13072-015-0035-3","article-title":"Characterization of whole-genome autosomal differences of DNA methylation between men and women","volume":"8","author":"Singmann","year":"2015","journal-title":"Epigenetics Chromatin."},{"issue":"1","key":"2020011304204386600_CIT0067","doi-asserted-by":"crossref","first-page":"14862","DOI":"10.1038\/s41598-018-33238-9","article-title":"Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus","volume":"8","author":"Hwang","year":"2018","journal-title":"Sci Rep."},{"issue":"4","key":"2020011304204386600_CIT0068","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","article-title":"High density DNA methylation array with single CpG site resolution","volume":"98","author":"Bibikova","year":"2011","journal-title":"Genomics."},{"issue":"1","key":"2020011304204386600_CIT0069","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol."}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsz198\/30268566\/zsz198.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/43\/1\/zsz198\/31778288\/zsz198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/43\/1\/zsz198\/31778288\/zsz198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T09:21:59Z","timestamp":1578907319000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsz198\/5574506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,26]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2020,1,13]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsz198","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,9,26]]},"article-number":"zsz198"}}