{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:50:11Z","timestamp":1793886611550,"version":"4.8.0"},"reference-count":102,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Israeli Ministry of Science and Technology"},{"name":"Adelis Foundation"},{"name":"Prince Center for Neurodegenerative Diseases"},{"name":"International Howard Hughes Medical Institute"},{"name":"Wellcome Trust researcher"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Increasing evidence highlight the involvement of immune cells in brain activity and its dysfunction. The brain\u2019s immune compartment is a dynamic ensemble of cells that can fluctuate even in naive animals. However, the dynamics and factors that can affect the composition of immune cells in the naive brain are largely unknown. Here, we examined whether acute sleep deprivation can affect the brain\u2019s immune compartment (parenchyma, meninges, and choroid plexus). Using high-dimensional mass cytometry analysis, we broadly characterized the effects of short-term sleep deprivation on the immune composition in the mouse brain. We found that after 6 h of sleep deprivation, there was a significant increase in the abundance of B cells in the brain compartment. This effect can be accounted for, at least in part, by the elevated expression of the migration-related receptor, CXCR5, on B cells and its ligand, cxcl13, in the meninges following sleep deprivation. Thus, our study reveals that short-term sleep deprivation affects the brain\u2019s immune compartment, offering a new insight into how sleep disorders can affect brain function and potentially contribute to neurodegeneration and neuroinflammation.<\/jats:p>","DOI":"10.1093\/sleep\/zsz222","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T14:41:59Z","timestamp":1569422519000},"source":"Crossref","is-referenced-by-count":18,"title":["Short-term sleep deprivation in mice induces B cell migration to the brain compartment"],"prefix":"10.1093","author":[{"given":"Ben","family":"Korin","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"},{"name":"Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimrit","family":"Avraham","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilla","family":"Azulay-Debby","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"},{"name":"Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Farfara","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"},{"name":"Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahed","family":"Hakim","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit, Rambam Health Care Campus, Haifa, Israel"},{"name":"Cancer Research Center, EMMS Hospital, Nazareth, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Rolls","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"},{"name":"Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"},{"name":"Technion Integrated Cancer Center (TICC), Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"issue":"8","key":"2019102000290452900_CIT0001","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tins.2016.05.002","article-title":"Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer\u2019s disease?","volume":"39","author":"Mander","year":"2016","journal-title":"Trends Neurosci."},{"key":"2019102000290452900_CIT0002","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.smrv.2014.03.007","article-title":"Sleep and Alzheimer\u2019s disease","volume":"19","author":"Peter-Derex","year":"2015","journal-title":"Sleep Med Rev"},{"issue":"5\u20136","key":"2019102000290452900_CIT0003","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000470904","article-title":"Sleep disorder as a triggering factor for relapse in multiple 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