{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:11:44Z","timestamp":1785352304814,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T00:00:00Z","timestamp":1569715200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of Health","award":["2751598"],"award-info":[{"award-number":["2751598"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To identify children who respond to oral iron supplementation as evidenced by increased ferritin levels and to identify factors that correlate with improvement in ferritin levels in those who respond.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective chart review of the PLMS\/RLS\/RSD database at Seattle Children\u2019s Hospital was carried out. Data collected included nocturnal polysomnography parameters, age, sex, initial and follow-up ferritin level and date of collection, and presence of restless legs syndrome (RLS), periodic limb movements of sleep (PLMS)\/PLM disorder (PLMD), restless sleep disorder (RSD), obstructive sleep apnea (OSA), neurologic, psychiatric, neurodevelopmental, or medical comorbidity. Oral iron therapy was evaluated by side effects (none; constipation; bad taste\/nausea), subjective outcome in symptoms (resolved, improved, no change), and adherence to therapy (poor, fair, good).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-seven children were included in this study of whom 42 were classified as responders (increase in ferritin of \u226510 \u00b5g\/L) and 35 were nonresponders. Age and sex were not different between groups. Adherence was the only significant predictor of an increase in ferritin of \u226510 \u00b5g\/L. Constipation was seen in 7.1% of responders vs. 45.8% of nonresponders. No change in symptoms was reported in 26.2% of responders vs. 71.4% in nonresponders. A significant correlation was found between treatment duration and ferritin level change in responders but not in nonresponders<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Side effects hinders adherence to oral iron supplementation in children. Responders to oral iron show improvement in ferritin levels and symptoms, while nonresponders show no improvement in ferritin levels despite a long-lasting treatment, at least in part of them.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsz234","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T08:21:47Z","timestamp":1569745307000},"source":"Crossref","is-referenced-by-count":15,"title":["Determinants of ferritin response to oral iron supplementation in children with sleep movement disorders"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-8426","authenticated-orcid":false,"given":"Lourdes M","family":"DelRosso","sequence":"first","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, WA"},{"name":"University of Washington, Seattle, WA"},{"name":"Seattle Children\u2019s Hospital, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Yi","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy H M","family":"Chan","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-6310","authenticated-orcid":false,"given":"Joanna E","family":"Wrede","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, WA"},{"name":"University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey T","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, WA"},{"name":"University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Oasi Research Institute - 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