{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:40Z","timestamp":1787009680336,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["5935"],"award-info":[{"award-number":["5935"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate differences in dual-energy X-ray absorptiometry (DXA) parameters, trabecular bone score (TBS), bone turnover markers and inactive matrix Gla protein (dp-ucMGP) between patients with obstructive sleep apnea (OSA) and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled 53 male patients diagnosed with OSA, and 50 age- and body mass index (BMI)-matched control subjects. All participants underwent DXA imaging, TBS assessment and blood sampling for biochemical analysis of bone metabolism markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean apnea\u2013hypopnea index (AHI) score of OSA patients was 43.8 \u00b1 18.8 events\/h. OSA patients had significantly higher plasma dp-ucMGP levels in comparison to controls (512.7 \u00b1 71.9 vs. 465.8 \u00b1 50.9 pmol\/L, p &lt; 0.001). OSA and control group did not significantly differ regarding standard DXA results, while TBS values were significantly lower in the OSA group (1.24 \u00b1 0.17 vs. 1.36 \u00b1 0.15, p &lt; 0.001). AHI score was a significant independent correlate of plasma dp-ucMGP levels (\u03b2 \u00b1 SE, 1.461 \u00b1 0.45, p = 0.002). In addition, TBS retained a significant relationship with dp-ucMGP values (\u03b2 \u00b1 SE, \u221293.77 \u00b1 38.1, p = 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>dp-ucMGP levels are significantly higher in patients with OSA and correlate with disease severity. In addition, TBS values in OSA patients are lower in comparison with the control group and decrease with disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsz243","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T01:59:14Z","timestamp":1571623154000},"source":"Crossref","is-referenced-by-count":7,"title":["Bone metabolism parameters and inactive matrix Gla protein in patients with obstructive sleep apnea\u2020"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-5063","authenticated-orcid":false,"given":"Marino","family":"Vilovic","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Dogas","sequence":"additional","affiliation":[{"name":"Sleep Medicine Centre, University of Split School of Medicine, and University Hospital of Split, Split, Croatia"},{"name":"Department of Neuroscience, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Ticinovic Kurir","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"},{"name":"Department of Endocrinology and Diabetology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4878-8146","authenticated-orcid":false,"given":"Josip A","family":"Borovac","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Supe-Domic","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostics, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Vilovic","sequence":"additional","affiliation":[{"name":"Health Centre of Split-Dalmatia County, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalija","family":"Ivkovic","sequence":"additional","affiliation":[{"name":"Sleep Medicine Centre, University of Split School of Medicine, and University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-4947","authenticated-orcid":false,"given":"Doris","family":"Rusic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anela","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josko","family":"Bozic","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"issue":"9918","key":"2019110523160260600_CIT0001","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet."},{"key":"2019110523160260600_CIT0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.smrv.2014.06.003","article-title":"Does obstructive sleep apnea cause endothelial dysfunction? 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