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Although the loss of Hypocretin\/Orexin (Hcrt\/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt\/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.<\/jats:p>","DOI":"10.1093\/sleep\/zsz296","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T01:46:27Z","timestamp":1578620787000},"source":"Crossref","is-referenced-by-count":34,"title":["A circuit perspective on narcolepsy"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-5175","authenticated-orcid":false,"given":"A R","family":"Adamantidis","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre for Experimental Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland"},{"name":"Department of Biomedical Research, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre for Experimental Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland"},{"name":"Ohio Sleep Medicine Institute, Dublin, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Biology, Program in Neuroscience, Williams College, Williamstown, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Burdakov","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Peyron","sequence":"first","affiliation":[{"name":"Center for Research in Neuroscience of Lyon, SLEEP team, CNRS UMR5292, INSERM U1028, University Lyon 1, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Scammell","sequence":"first","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"issue":"1","key":"2020051204581914200_CIT0001","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc Natl Acad Sci USA."},{"issue":"4","key":"2020051204581914200_CIT0002","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding 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