{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:14Z","timestamp":1787009654713,"version":"build-2736575974"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":124,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1U01AG051412"],"award-info":[{"award-number":["1U01AG051412"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG068054"],"award-info":[{"award-number":["U19AG068054"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K99AG065506"],"award-info":[{"award-number":["K99AG065506"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Centralized Repository for Alzheimer Disease and Related Dementias","award":["U24 AG21886"],"award-info":[{"award-number":["U24 AG21886"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We determined the extent to which obstructive sleep apnea (OSA) is associated with increased cerebrovascular disease and amyloid burden, and the relation of the two processes across clinical Alzheimer\u2019s disease (AD) diagnostic groups in adults with Down syndrome (DS). Adults with DS from the Biomarkers of Alzheimer\u2019s Disease in Down Syndrome (ADDS) study were included given available research MRI (n = 116; 50 \u00b1 8 years; 42% women) and amyloid PET scans (n = 71; 50 \u00b1 7 years; 39% women) at the time of analysis. Participants were characterized as cognitively stable (CS; 64%), with mild cognitive impairment-DS (MCI-DS; 23%), with possible AD dementia (5%), or with definite AD dementia (8%). OSA was determined via medical records and interviews. Models tested the effect of OSA on MRI-derived cerebrovascular biomarkers and PET-derived amyloid burden, and the moderating effect of OSA and AD diagnosis on biomarkers. OSA was reported in 39% of participants, which did not differ by clinical AD diagnostic group. OSA was not associated with cerebrovascular biomarkers but was associated with greater cortical amyloid burden. White matter hyperintensity (WMH) volume (primarily in the parietal lobe), enlarged perivascular spaces, and cortical and striatal amyloid burden were greater across clinical AD diagnostic groups (CS&amp;lt;MCI-DS&amp;lt;possible AD&amp;lt;definite AD). OSA increased the differences in WMH volumes across clinical AD diagnostic groups, primarily in the frontal and temporal lobes. Adults with DS and OSA had greater amyloid burden and greater cerebrovascular disease with AD. Importantly, OSA may be a modifiable risk factor that can be targeted for intervention in this population at risk for AD.<\/jats:p>","DOI":"10.1093\/sleepadvances\/zpac013","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T18:36:22Z","timestamp":1651775782000},"source":"Crossref","is-referenced-by-count":20,"title":["Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer\u2019s continuum"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-3547","authenticated-orcid":false,"given":"Patrick","family":"Lao","sequence":"first","affiliation":[{"name":"Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-5369","authenticated-orcid":false,"given":"Molly E","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fordham University , Bronx, NY 10458 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigan L","family":"Hartley","sequence":"additional","affiliation":[{"name":"Waisman Center, University of Wisconsin-Madison , Madison, WI, 53706 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8078","authenticated-orcid":false,"given":"Jos\u00e9","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keator","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay C","family":"Igwe","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal K","family":"Laing","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejania","family":"Cotton-Samuel","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra","family":"Sathishkumar","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmida","family":"Moni","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Andrews","sequence":"additional","affiliation":[{"name":"Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities , Staten Island, NY 10314 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Krinsky-McHale","sequence":"additional","affiliation":[{"name":"Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities , Staten Island, NY 10314 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Lee","sequence":"additional","affiliation":[{"name":"Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard University , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Yassa","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Diana Rosas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard University , Boston, MA 02114 , USA"},{"name":"Department of Radiology, Athinoula Martinos Center, Massachusetts General Hospital, Harvard University , Charlestown, MA 02129 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira T","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schupf","sequence":"additional","affiliation":[{"name":"Gertrude. 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