{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:43:04Z","timestamp":1780634584925,"version":"3.54.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Fatigue, brain fog, and sleep disturbance are among the most common symptoms of postacute sequelae of SARS-CoV-2 infection (PASC). We sought to determine the impact of sleep disruption on cognition and quality of life in patients with neurologic manifestations of PASC (Neuro-PASC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-nine patients were recruited from Neuro-COVID-19 clinic. Mean age was 48.1 years, 71.8% were female, and 82% were never hospitalized for COVID-19. Patients were evaluated via clinical assessment, quality-of-life measures in domains of cognitive function, fatigue, sleep disturbance, anxiety, and depression, NIH Toolbox cognitive tests, and 7 days of wrist actigraphy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median number of neurologic symptoms attributed to PASC was 6, with brain fog being the most common in 89.7%. Regarding non-neurologic symptoms, 94.9% complained of fatigue and 74.4% of insomnia. Patients reported significant impairment in all quality-of-life domains and performed worse in a task of attention compared to a normative US population. Actigraphy showed Neuro-PASC patients had lower sleep efficiency, longer sleep latency (both p\u2005&amp;lt;\u20050.001), and later sleep midpoint (p\u2005=\u20050.039) compared to 71 age-matched healthy controls with no PASC history. Self-reported cognitive symptoms correlated with the severity of fatigue (p\u2005&amp;lt;\u20050.001), anxiety (p\u2005=\u20050.05), and depression (p\u2005&amp;lt;\u20050.01). Objective evidence of sleep disruption measured by wakefulness after sleep onset, sleep efficiency, and latency were associated with decreased performance in attention and processing speed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prospective studies including larger populations of patients are needed to fully determine the interplay of sleep disruption on the cognitive function and quality of life of patients with PASC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpae002","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T07:42:35Z","timestamp":1705045355000},"source":"Crossref","is-referenced-by-count":10,"title":["Impact of sleep disruption on cognitive function in patients with postacute sequelae of SARS-CoV-2 infection: initial findings from a Neuro-COVID-19 clinic"],"prefix":"10.1093","volume":"5","author":[{"given":"Kathryn J","family":"Reid","sequence":"first","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis T","family":"Ingram","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millenia","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S","family":"Orban","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-9649","authenticated-orcid":false,"given":"Sabra M","family":"Abbott","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"},{"name":"Center for Circadian and Sleep Medicine, 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