{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:35:50Z","timestamp":1787880950173,"version":"build-2784847793"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VA HSR&D Service Research","award":["#RCS 20-191"],"award-info":[{"award-number":["#RCS 20-191"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Sleep-disordered breathing (SDB) is common in the Veteran population. In this retrospective study, we investigated the prevalence of comorbid central and obstructive SDB and the response rate to PAP among Veterans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Veterans were screened from a single VA medical center who had polysomnography (PSG) study from 2017 to 2021 to ascertain the presence, severity, and type of SDB by measuring the apnea\u2013hypopnea index (AHI) and central apnea index (CAI). Patients were excluded if they did not have complete studies (diagnostic and PAP titration studies). The inclusion criteria for these analyses were central sleep apnea (CSA) defined as AHI\u2005\u2265\u200510 events\/hour and CAI\u2005\u2265\u20055 events\/hour. Diagnostic \u201cCSA only\u201d was defined as AHI\u2005\u2265\u200510 events\/hour and CAI\u2005\u2265\u200550% of AHI. \u201cOSA only\u201d was defined if AHI\u2005\u2265\u200510 events\/hour and CAI\u2005&amp;lt;\u20055 events\/hour. Comorbid central and obstructive sleep apnea (COSA) was defined if AHI\u2005\u2265\u200510 events\/hour and CAI\u2005&amp;gt;\u20055 events\/hour but\u2005&amp;lt;\u200550% of AHI. The responsiveness to PAP therapy was determined based on the CAI\u2005&amp;lt;\u20055 events\/hour on the titration study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 90 patients met the inclusion criteria and from those 64 Veterans were found to have COSA (71%), 18 (20%) were CSA only, and 8 (9%) were OSA only. A total of 22 (24.4%) Veterans diagnosed with CSA or COSA were responsive to PAP therapy. Sixty days after treatment initiation, both responsive and nonresponsive groups had significant decreases in AHI and CAI (p\u2005&amp;lt;\u20050.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Comorbid central and obstructive SDB is common among Veterans. The response to PAP therapy is suboptimal but improves over time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpae011","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T17:35:23Z","timestamp":1707154523000},"source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of central sleep apnea among veterans and response rate to continuous positive airway pressure therapy"],"prefix":"10.1093","volume":"5","author":[{"given":"Nesrine Adly","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-3375","authenticated-orcid":false,"given":"Abdulghani","family":"Sankari","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"},{"name":"Department of Medical Education, Ascension Providence Hospital , Southfield, MI , USA \u00b8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Aldwaikat","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishtha","family":"Pandya","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Chowdhuri","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0849-3391","authenticated-orcid":false,"given":"Jennifer L","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine at the University of California , Los Angeles, CA , USA"},{"name":"Geriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salam","family":"Zeineddine","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. Dingell VA Medical Center , Detroit, MI , USA"},{"name":"Department of Internal Medicine, Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-5243","authenticated-orcid":false,"given":"M Safwan","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Medicine, John D. 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