{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:22:54Z","timestamp":1779211374387,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":72,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Symptom impact and neurocognitive function have not been previously compared between patients with obesity-associated hypoventilation disorders (obesity hypoventilation syndrome [OHS]) and hypoventilation in the setting of obesity and obstructive airways disease (OHAD). The aim of this study is to compare baseline sleep-related symptoms, health-related quality of life, and neurocognitive function between OHS and OHAD and the impact of PAP therapy on these outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Epworth Sleepiness Scale (ESS), Pittsburgh Sleepiness Quality Index (PSQI), SF36, and various neurocognitive tests, in addition to anthropometric, polysomnography, lung function, and blood gas data from participants with OHS and participants with OHAD, were included in the analysis. These data were originally collected in their respective randomized clinical trials, comparing the efficacy of different PAP modes (bilevel PAP vs. CPAP) in resolving hypercapnia. Between groups (OHS vs OHAD), pre- and post-treatment (with 3 months of positive airway pressure) comparisons were made using linear mixed modeling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>45 OHS participants (mean age 51 years old, 33% female, BMI 52\u00a0kg\/m2, FER 0.81, PaCO2 54 mmHg, AHI 87\/h) and 32 OHAD participants (mean age 61years old, 31% female, BMI 43kg\/m2, FER 0.60, PaCO2 54 mmHg, AHI 59\/h) were included in the analysis. Both OHS and OHAD had similar baseline ESS (14(5.6) vs. 12(5.4)), Global PSQI (10(3.2) vs. 11(4.8)), SF36 and neurocognitive test performances (other than OHAD had lower digit symbol substitution test performance). Treatment with PAP therapy resulted in similar ESS, Global PSQI, and SF36 improvements in both groups. Neurocognitive performance did not significantly improve after PAP therapy in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The symptom impact between two separate hypoventilation disorders (OHS and OHAD), in terms of sleepiness, sleep quality, quality of life, and cognitive function, were similar. OHS and OHAD had similar treatment responses in these parameters after 3 months of PAP therapy.<\/jats:p>\n                  <jats:p>Nocturnal ventilatory support in OHS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpae016","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:27:54Z","timestamp":1710340074000},"source":"Crossref","is-referenced-by-count":3,"title":["A comparison of two obesity-related hypoventilation disorders: Impact on sleep, quality of life and neurocognitive outcomes and the effects of positive airway pressure\u00a0therapy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-2693","authenticated-orcid":false,"given":"Yizhong","family":"Zheng","sequence":"first","affiliation":[{"name":"Sleep and Circadian Research Group,\u00a0Woolcock Institute of Medical Research , Sydney, NSW 2037 , Australia"},{"name":"Central Clinical School, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Department of Respiratory and Sleep Medicine,\u00a0Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"},{"name":"Department of Respiratory and Sleep Medicine,\u00a0St George Hospital , Sydney, NSW 2217 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon J","family":"Yee","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Research Group,\u00a0Woolcock Institute of Medical Research , Sydney, NSW 2037 , Australia"},{"name":"Central Clinical School, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Department of Respiratory and Sleep Medicine,\u00a0Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-5233","authenticated-orcid":false,"given":"Keith","family":"Wong","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Research Group,\u00a0Woolcock Institute of Medical Research , Sydney, NSW 2037 , Australia"},{"name":"Central Clinical School, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Department of Respiratory and Sleep Medicine,\u00a0Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald R","family":"Grunstein","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Research Group,\u00a0Woolcock Institute of Medical Research , Sydney, NSW 2037 , Australia"},{"name":"Central Clinical School, University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J","family":"Piper","sequence":"additional","affiliation":[{"name":"Central Clinical School, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Department of Respiratory and Sleep Medicine,\u00a0Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"issue":"151","key":"2024040315540608600_CIT0001","doi-asserted-by":"crossref","first-page":"180097","DOI":"10.1183\/16000617.0097-2018","article-title":"Obesity hypoventilation syndrome","volume":"28","author":"Masa","year":"2019","journal-title":"Eur Respir Rev"},{"issue":"1","key":"2024040315540608600_CIT0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11325-003-0003-1","article-title":"Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome","volume":"7","author":"Hida","year":"2003","journal-title":"Sleep Breath"},{"issue":"3","key":"2024040315540608600_CIT0003","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1378\/chest.10-2531","article-title":"Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial. 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