{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:18:25Z","timestamp":1753877905737,"version":"3.41.2"},"reference-count":137,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":91,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>What an honor to write about Dr. Edward O. Bixler\u2019s contributions to the sleep field. In 1967, Dr. Bixler published a case report on a chimpanzee with implanted brain electrodes while working at an Air Force base in New Mexico. A few years later, in 1971, he published on the sleep effects of flurazepam in individuals with insomnia together with Dr. Anthony Kales, data that he had collected when the Sleep Research &amp; Treatment Center (SRTC) was housed at the University of California Los Angeles. Dr. Bixler, a meticulous scientist, learned from Dr. Kales, a devoted clinician, to study \u201cthe whole patient, and all aspects of sleep,\u201d a legacy that continued when the SRTC moved to Penn State in Hershey. Indeed, Dr. Bixler\u2019s tenure at Penn State from 1971 until 2019 kept the science of the SRTC focused on that premise and helped translate scientific evidence into clinical care. He not only contributed early to the pharmacology of sleep and the effects of hypnotics, but he was also a pioneer in \u201csleep epidemiology.\u201d His \u201cPrevalence of sleep disorders in the Los Angeles metropolitan area\u201d study of 1979 was the first rigorous epidemiological study on sleep disturbances. Starting in 1990, he established the Penn State Adult Cohort to estimate the prevalence and natural history of sleep-disordered breathing and other sleep disorders in adults. Inspired by life-course epidemiology, he established in 2001 the Penn State Child Cohort to estimate the same phenomena in children. This Living Legend paper captures and highlights Dr. Bixler\u2019s enduring legacy to sleep science.<\/jats:p>","DOI":"10.1093\/sleepadvances\/zpae020","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T11:42:43Z","timestamp":1711971763000},"source":"Crossref","is-referenced-by-count":0,"title":["Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-6161","authenticated-orcid":false,"given":"Julio","family":"Fernandez-Mendoza","sequence":"first","affiliation":[{"name":"Sleep Research & Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine , Hershey, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Sleep Research & Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine , Hershey, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward O","family":"Bixler","sequence":"additional","affiliation":[{"name":"Sleep Research & Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine , Hershey, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"2024040111421729900_CIT0001","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3758\/BF03210267","article-title":"Latency of the blink reflex and stimulus intensity","volume":"2","author":"Bixler","year":"1967","journal-title":"Percept Psychophys"},{"issue":"1","key":"2024040111421729900_CIT0002","first-page":"91","article-title":"Rapid decompression in a chimpanzee with implanted electrodes: a case report","volume":"23","author":"Reite","year":"1967","journal-title":"Electroencephalogr Clin Neurophysiol."},{"key":"2024040111421729900_CIT0003","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00401529","article-title":"The effect of monoamine oxidase inhibitors on paradoxical sleep in the 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