{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:10:57Z","timestamp":1789103457842,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","award":["A-09-PGI\/IMP\/80\/2019"],"award-info":[{"award-number":["A-09-PGI\/IMP\/80\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Studies have indicated that sleep abnormalities are a strong risk factor for developing cognitive impairment, cardiomyopathies, and neurodegenerative disorders. However, neuroimaging modalities are unable to show any consistent markers in obstructive sleep apnea (OSA) patients. We hypothesized that, compared with those of the control cohort, advanced diffusion MRI metrics could show subtle microstructural alterations in the brains of patients with OSA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixteen newly diagnosed patients with moderate to severe OSA and 15 healthy volunteers of the same age and sex were considered healthy controls. Multishell diffusion MRI data of the brain, along with anatomical data (T1 and T2 images), were obtained on a 3T MRI system (Siemens, Germany) after a polysomnography (PSG) test for sleep abnormalities and a behavioral test battery to evaluate cognitive and executive brain functions. Diffusion MRI data were used to compute diffusion tensor imaging and diffusion kurtosis imaging (DKI) parameters along with white-matter tract integrity (WMTI) metrics for only parallel white-matter fibers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>OSA was diagnosed when the patient\u2019s apnea\u2013hypopnea index was\u2005\u2265\u200515. No significant changes in cognitive or executive functions were observed in the OSA cohort. DKI parameters can show significant microstructural alterations in the white-matter region, while the WMTI metric, the axonal-water-fraction (fp), reveals a significant decrease in OSA patients concerning the control cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Advanced diffusion MRI-based microstructural alterations in the white-matter region of the brain suggest that white-matter tracts are more sensitive to OSA-induced intermittent hypoxia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpae031","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T12:43:33Z","timestamp":1716554613000},"source":"Crossref","is-referenced-by-count":4,"title":["Biophysical modeling and diffusion kurtosis imaging reveal microstructural alterations in normal-appearing white-matter regions of the brain in obstructive sleep apnea"],"prefix":"10.1093","volume":"5","author":[{"given":"Zia","family":"Hashim","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, SGPGIMS , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, SGPGIMS , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar","family":"Neyaz","sequence":"additional","affiliation":[{"name":"Department of Radio-diagnosis, SGPGIMS , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, SGPGIMS , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Neurology, SGPGIMS , Lucknow , 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