{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:33:42Z","timestamp":1784662422246,"version":"3.55.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":170,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Sleep deprivation is highly prevalent and caused by conditions such as night shift work or illnesses like obstructive sleep apnea. Compromised sleep affects cardiovascular-, immune-, and neuronal systems. Recently, we published human serum proteome changes after a simulated night shift. This pilot proteomic study aimed to further explore changes in human blood serum after 6 hours of sleep deprivation at night.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Human blood serum samples from eight self-declared healthy females were analyzed using Orbitrap Eclipse mass spectrometry (MS-MS) and high-pressure liquid chromatography. We used a within-participant design, in which the samples were taken after 6 hours of sleep at night and after 6 hours of sleep deprivation the following night. Systems biological databases and bioinformatic software were used to analyze the data and comparative analysis were done with other published sleep-related proteomic datasets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 494 proteins, 66 were found to be differentially expressed proteins (DEPs) after 6 hours of sleep deprivation. Functional enrichment analysis revealed the associations of these DEPs with several biological functions related to the altered regulation of cellular processes such as platelet degranulation and blood coagulation, as well as associations with different curated gene sets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study presents serum proteomic changes after 6 hours of sleep deprivation, supports previous findings showing that short sleep deprivation affects several biological processes, and reveals a molecular signature of proteins related to pathological conditions such as altered coagulation and platelet function, impaired lipid and immune function, and cell proliferation. Data are available via ProteomeXchange with identifier PXD045729. This paper is part of the Genetic and other molecular underpinnings of sleep, sleep disorders, and circadian rhythms including translational approaches Collection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpae042","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:25:36Z","timestamp":1718781936000},"source":"Crossref","is-referenced-by-count":9,"title":["Human serum proteomics reveals a molecular signature after one night of sleep deprivation"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-1983","authenticated-orcid":false,"given":"Alvhild Alette","family":"Bj\u00f8rkum","sequence":"first","affiliation":[{"name":"Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandra","family":"Griebel","sequence":"additional","affiliation":[{"name":"Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences , Bergen , Norway"},{"name":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Even","family":"Birkeland","sequence":"additional","affiliation":[{"name":"The Proteomics Unit at The Department of Biomedicine, University of Bergen , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"issue":"6","key":"2024080908172728100_CIT0001","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1007\/s11325-023-02828-x","article-title":"Sleep insufficiency, circadian rhythms, and metabolomics: the connection between 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