{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:40:03Z","timestamp":1778276403008,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Sleep Disordered Breathing Team Grant"},{"name":"BC Lung Association Operating Grant"},{"name":"Canadian Sleep and Circadian Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>There is a higher risk of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) and innate immunity is a potential pathophysiologic pathway. The objective of this study was to determine whether nocturnal hypoxemia is associated with circulating markers of innate immunity in OSA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study of an observational cohort from the multicentre, clinic-based, Canadian Sleep and Circadian Network. Oxygen desaturation index 4% (ODI4%) was used to diagnose and determine the severity of OSA. The percentage of time spent below SpO2 &amp;lt;90% (T90) and minimum SpO2 we considered as other measures of nocturnal hypoxemia. Multiple linear regressions were used to assess associations between total white blood cell (WBC) and subsets and ODI and hypoxemia indices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1296 patients were included in the analysis. There was a positive association between ODI4% and lymphocyte count, adjusting for confounders. For every 1-SD increase in ODI4%, lymphocyte counts increased by 0.08\u2005\u00d7\u2005109 L (95% CI 0.01 to 0.15) SD. Patients with severe OSA (ODI4%\u2005\u2265\u200530 events\/hour) had significantly higher total WBC and lymphocyte count than non-OSA cohort, in the adjusted model, p-value &amp;lt;.02, for both. There was a positive association between T90 and total WBC, neutrophil, lymphocyte, and monocyte count, adjusting for confounders. Minimum SpO2 was independently associated with total WBC, neutrophil, and monocyte counts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this pan-Canadian clinic-based cohort of individuals with suspected OSA, nocturnal hypoxemia indices were associated with an increase in total WBC and subset counts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpaf028","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T15:19:46Z","timestamp":1749482386000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of nocturnal hypoxemia and white blood cell count in a multicenter cohort"],"prefix":"10.1093","volume":"6","author":[{"given":"Aditi","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of British Columbia , Vancouver, Brititsh 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Medicine, Cumming School of Medicine, University of Calgary , Calgary, Alberta,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kimoff","sequence":"additional","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre , Montreal, Quebec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-5765","authenticated-orcid":false,"given":"Frederic","family":"Series","sequence":"additional","affiliation":[{"name":"Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (IUCPQ-UL) , Quebec City, Quebec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Lajoie","sequence":"additional","affiliation":[{"name":"Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (IUCPQ-UL) , Quebec City, Quebec,","place":["Canada"]},{"name":"Multidisciplinary Department of Respiratory Medicine and Thoracic Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (IUCPQ) , Quebec City, Quebec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-997X","authenticated-orcid":false,"given":"Rebecca","family":"Robillard","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Ottawa , Ottawa, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Jen","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of British Columbia , Vancouver, Brititsh Columbia,","place":["Canada"]},{"name":"Leon Judah Blackmore Sleep Disorders Program, UBC Hospital , Vancouver, Brititsh 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