{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:43:26Z","timestamp":1773323006463,"version":"3.50.1"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"International Parkinson\u2019s Disease Genomics Consortium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Among the latter, sleep disturbances are particularly common and include insomnia, obstructive sleep apnea (OSA), and excessive daytime sleepiness. Here, we investigated the shared genetic architecture between PD and sleep-related traits to uncover biological pathways that underpin this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed genome-wide association study (GWAS) summary statistics for PD (~37.7\u00a0K cases, ~18.6\u00a0K proxy cases, ~1.4\u00a0M controls) and eight self-reported sleep-related traits (each with n\u2009&amp;gt;\u2009300\u2009000): ease of getting up, chronotype (morningness), napping, insomnia, OSA, snoring, daytime dozing, and sleep duration. Genetic correlations were estimated using Linkage Disequilibrium (LD) score regression, and GWAS-pairwise analysis was used to identify genomic segments harboring shared causal variants. We then mapped these variants to protein-coding genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a genome-wide genetic correlation between PD and daytime dozing (p\u2009&amp;lt;\u2009.05). A separate, local-level analysis identified six genomic regions harboring shared causal variants between PD and other sleep-related traits (primarily ease of getting up and napping). The most statistically significant of these local associations was observed at a single locus on chromosome 17, which contains the majority of mapped protein-coding genes, including ARHGAP27, PLEKHM1, CRHR1, and MAPT. These genes are implicated in neurodegeneration and circadian rhythm regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that the MAPT locus, beyond its established role in PD, may also contribute to sleep\u2013wake regulation via shared biological pathways, including tau pathology, stress response, and chromatin remodeling. Our results highlight sleep disturbances as a potential early marker or risk factor of PD.<\/jats:p>\n                    <jats:p>Statement of Significance Sleep disturbances are one of the most common non-motor symptoms of Parkinson\u2019s disease (PD), sometimes manifesting years before motor symptoms emerge, yet the genetic factors underlying this relationship remain poorly understood. Our study identifies shared risk loci in six genomic segments, highlighting a key region on chromosome 17 linked to both neurodegeneration and sleep\u2013wake regulation. This work fills a critical gap by revealing specific genes and biological pathways that may drive both disease onset and sleep disruption. Future research should explore these pathways in diverse populations and investigate their potential as early biomarkers for interventions to screen or prevent PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpag010","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:59:42Z","timestamp":1769086782000},"source":"Crossref","is-referenced-by-count":0,"title":["Shared genetic architecture between Parkinson\u2019s disease and self-reported sleep-related traits implicates the\n                    <i>MAPT<\/i>\n                    locus on chromosome 17"],"prefix":"10.1093","volume":"7","author":[{"given":"Aura","family":"Aguilar-Rold\u00e1n","sequence":"first","affiliation":[{"name":"Brain and Mental Health Program, QIMR Berghofer Medical Research Institute , Brisbane, QLD ,","place":["Australia"]},{"name":"Licenciatura en Ciencias Gen\u00f3micas, Escuela Nacional de Estudios Superiores Unidad Juriquilla , , Quer\u00e9taro ,","place":["M\u00e9xico"]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico , , Quer\u00e9taro ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia S","family":"Ogonowski","sequence":"additional","affiliation":[{"name":"Brain and Mental Health Program, QIMR Berghofer Medical Research Institute , Brisbane, QLD ,","place":["Australia"]},{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , Brisbane, QLD ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel E","family":"Renter\u00eda","sequence":"additional","affiliation":[{"name":"Brain and Mental Health Program, QIMR Berghofer Medical Research Institute , Brisbane, QLD ,","place":["Australia"]},{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , Brisbane, QLD ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M","family":"Garc\u00eda-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Brain and Mental Health Program, QIMR Berghofer Medical Research Institute , Brisbane, QLD ,","place":["Australia"]},{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , Brisbane, QLD ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"13","key":"2026031117162067000_ref1","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: a systematic review and meta-analysis: PD PREVALENCE","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov Disord"},{"issue":"5","key":"2026031117162067000_ref2","first-page":"103","article-title":"Clinical features of Parkinson\u2019s disease: the evolution of critical 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