{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:01:44Z","timestamp":1777946504964,"version":"3.51.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Sciences and Engineering Research Council (NSERC) of Canada","award":["10025902"],"award-info":[{"award-number":["10025902"]}]},{"name":"Brenda Strafford Foundation Chair in Alzheimer Research","award":["RT751959"],"award-info":[{"award-number":["RT751959"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) impacts brain structure and cerebrovascular function and is often associated with impaired sleep microstructure such as sleep spindles. Given the lack of research in sleep spindles and brain physiology in community dwelling older adults, this exploratory study hypothesized that (1) sleep disordered breathing is associated with lower cortical thickness, thalamic volume, hippocampal volume, cerebral perfusion, and higher white matter hyperintensity (WMH) volume; and (2) greater cortical thickness, thalamic and hippocampal volume predict greater sleep spindle density, frequency and percentage of fast spindles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 71 participants (males\/females: 24\/47) underwent magnetic resonance imaging, and sleep polysomnography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Apnea hypopnea index, oxygen desaturation index, and sleep fragmentation index were not related to daytime whole brain gray matter cerebral blood flow or WMH volume (all p\u00a0&amp;gt;\u2009.05). Spindle frequency was associated with thalamic volume (\u03b2\u2009=\u20090.24, p\u2009=\u2009.03, 95% CI\u2009=\u20090.20\u20133.66) but this finding did not survive correction for multiple comparisons. Hippocampal volume and cortical thickness were not associated with sleep spindle characteristics (all p\u00a0&amp;gt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest a potential structure\u2013function relationship between the thalamus and spindle frequency. Our results also demonstrate that cerebral perfusion and white matter hyperintensities are not associated with OSA in community-dwelling older adults, potentially reflecting an ability of the cerebrovasculature to cope with relatively mild hypoxic insults. However, future studies should confirm these findings in a larger sample and consider the length of time in which participants experienced mild to moderately severe OSA (apnea hypopnea index &amp;lt;30).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpag028","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:28:40Z","timestamp":1773664120000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploratory associations of sleep spindles and sleep disordered breathing indices with hippocampal and thalamic volume, and cortical thickness, and cerebrovascular biomarkers among community dwelling older adults: results from the Brain in Motion Study"],"prefix":"10.1093","volume":"7","author":[{"given":"Alison M H","family":"Donald","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-7232","authenticated-orcid":false,"given":"Andrew E","family":"Beaudin","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matiram","family":"Pun","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Science and Technology, University of New England , Armidale, NSW ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandy L","family":"Callahan","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Department of Psychology, Faculty of Arts, University of Calgary , Calgary, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G Bruce","family":"Pike","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-6801","authenticated-orcid":false,"given":"Marc J","family":"Poulin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Faculty of Kinesiology, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary , Calgary, AB ,","place":["Canada"]},{"name":"Libin 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