{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:22:11Z","timestamp":1787865731622,"version":"build-2784847793"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":206,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL164454"],"award-info":[{"award-number":["R01-HL164454"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL153969"],"award-info":[{"award-number":["R01-HL153969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL146751"],"award-info":[{"award-number":["R01-HL146751"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-DK107859"],"award-info":[{"award-number":["R01-DK107859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35-GM146839"],"award-info":[{"award-number":["R35-GM146839"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01-HL136884"],"award-info":[{"award-number":["K01-HL136884"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massachusetts General Hospital Claflin Distinguished Scholar Award"},{"name":"Massachusetts General Hospital Mc Cancer Center SPARC Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>To test the feasibility of a self-directed, in-home, contactless salivary dim light melatonin onset (DLMO) assessment protocol to remotely measure endogenous circadian phase in participants with circadian rhythm disorders and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The 4\u20136-week protocol involved sleep, activity, and light tracking, sleep diaries, questionnaires, and two self-directed at-home salivary sample collections for DLMO one week apart with objective compliance measures. Individuals participated remotely using an online portal and received a mailed kit. The study population included five cases with Circadian-Rhythm Sleep\u2013Wake Disorders and five controls ages 27-63.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Salivary DLMO times could be calculated for 14\/20 assessments, resulting in 8\/10 participants with at least 1 valid DLMO and 6\/10 having valid DLMOs for both. Failures in DLMOs resulted from compliance errors (eg, bright light levels) or consistently below\/above threshold melatonin levels. After completing the DLMO collections, 70% of participants felt confident after completing DLMO 1, while 90% felt confident after DLMO 2. DLMO occurred on average at 24.08\u00a0hours (SEM\u2009=\u20091.10\u00a0hours) for four participants with Delayed Sleep Wake Phase Disorder, and at 21.37\u00a0hours (SEM\u2009=\u20090.71\u00a0hours) for five controls. The first and second DLMOs were strongly correlated (r\u2009=\u20090.98, p\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate that contactless, self-directed, at-home DLMO assessments are feasible, reliable, and capable of detecting clinically relevant differences in circadian timing. The current protocol may serve as a framework to reliably and scalably assess circadian phase in both clinical and general populations.<\/jats:p>\n                    <jats:p>Statement of Significance Here, we report results of a pilot study regarding feasibility and accuracy of the first contactless, self-directed dim-light melatonin assessments, requiring no in-lab visitations. Our results indicate that contactless, self-directed, at-home dim light melatonin onset assessments are feasible, reliable and capable of detecting clinically relevant differences in circadian timing. This pilot study addresses the needs of a diverse patient population by increasing accessibility and simplifying diagnostic tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpag081","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:43:37Z","timestamp":1784893417000},"source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of a contactless, self-directed, home-based dim-light melatonin onset protocol: the Circadia pilot study"],"prefix":"10.1093","volume":"7","author":[{"given":"Gregory","family":"Bormes","sequence":"first","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital , Boston, MA \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J","family":"Love","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital , Boston, MA 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