{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:16:19Z","timestamp":1789348579335,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"R-Bio Co., Ltd","award":["2017-01-012"],"award-info":[{"award-number":["2017-01-012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although successful short-term results of the intra-articular injection of mesenchymal stem cells (MSCs) for the conservative treatment of knee osteoarthritis (OA) have been reported, the mid-term results of the injection of adipose-derived (AD) MSCs remains unknown. We assessed the mid-term safety and efficacy of the intra-articular injection of ADMSCs in patients with knee OA. Eleven patients with knee OA were prospectively enrolled and underwent serial evaluations during a 5-year follow-up of a single intra-articular injection of autologous high-dose (1.0 \u00d7 108) ADMSCs. The safety profiles were assessed using the World Health Organization Common Toxicity Criteria. The clinical evaluations included visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for pain and function, respectively. The radiologic evaluations included chondral defect area and whole-organ magnetic resonance imaging scores (WORMS) by serial magnetic resonance imaging (MRI). Hip-knee-ankle axis (HKAA) and Kellgren-Lawrence (K-L) grades were assessed on simple radiographs. No treatment-related adverse events occurred during the 5-year follow-up. Both VAS and total WOMAC scores improved significantly at 6 months after the injection and until the latest follow-up. Total WORMS was significantly improved until 3 years after the injection. However, the chondral defect size on MRI or other radiologic evaluations did not change significantly. A single intra-articular injection of autologous, high-dose ADMSCs provided safe and clinical improvement without radiologic aggravation for 5 years. Furthermore, structural changes in the osteoarthritic knee showed significant improvement up to 3 years, suggesting a possible option for disease-modifying outpatient treatment for patients with knee OA.<\/jats:p>","DOI":"10.1093\/stcltm\/szac024","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:12:37Z","timestamp":1649934757000},"page":"586-596","source":"Crossref","is-referenced-by-count":36,"title":["Safety and Efficacy of the Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritic Knee: A 5-Year Follow-up Study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-1063","authenticated-orcid":false,"given":"Kang-Il","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Center for Joint Diseases, Kyung Hee University Hospital at Gangdong , Seoul , South Korea"},{"name":"Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, College of Medicine, Gangnam Severance Hospital, Yonsei University , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-2859","authenticated-orcid":false,"given":"Jun-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Center for Joint Diseases, Kyung Hee University Hospital at Gangdong , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Kwon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Center for Joint Diseases, Kyung Hee University Hospital at Gangdong , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kyung Hee University Hospital at Gandong , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"issue":"6","key":"2022062217023183700_CIT0001","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/cells10061365","article-title":"Meta-analysis of adipose tissue derived cell-based therapy for the treatment of knee osteoarthritis","volume":"10","author":"Agarwal","year":"2021","journal-title":"Cells."},{"key":"2022062217023183700_CIT0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41536-018-0041-8","article-title":"Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative 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