{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:53:49Z","timestamp":1788245629711,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["R01 AR070773"],"award-info":[{"award-number":["R01 AR070773"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"publisher","award":["R21 DE027922"],"award-info":[{"award-number":["R21 DE027922"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-1-0336"],"award-info":[{"award-number":["W81XWH-18-1-0336"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-10613"],"award-info":[{"award-number":["W81XWH-18-10613"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0795"],"award-info":[{"award-number":["W81XWH-20-1-0795"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0302"],"award-info":[{"award-number":["W81XWH-20-1-0302"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-18-027-01-CSM"],"award-info":[{"award-number":["RSG-18-027-01-CSM"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maryland Stem Cell Research Foundation","award":["2019-MSCRFD-5074"],"award-info":[{"award-number":["2019-MSCRFD-5074"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM123069"],"award-info":[{"award-number":["R01GM123069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071379"],"award-info":[{"award-number":["R01AR071379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61 AR078072-01"],"award-info":[{"award-number":["R61 AR078072-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American College of Surgeons Clowes"},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-1-0653"],"award-info":[{"award-number":["W81XWH-18-1-0653"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-19-PROP-ARA"],"award-info":[{"award-number":["W81XWH-19-PROP-ARA"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Heterotopic ossification (HO) is a pathologic process characterized by the formation of bone tissue in extraskeletal locations. The hip is a common location of HO, especially as a complication of arthroplasty. Here, we devise a first-of-its-kind mouse model of post-surgical hip HO and validate expected cell sources of HO using several HO progenitor cell reporter lines. To induce HO, an anterolateral surgical approach to the hip was used, followed by disclocation and acetabular reaming. Animals were analyzed with high-resolution roentgenograms and micro-computed tomography, conventional histology, immunohistochemistry, and assessments of fluorescent reporter activity. All the treated animals\u2019 developed periarticular HO with an anatomical distribution similar to human patients after arthroplasty. Heterotopic bone was found in periosteal, inter\/intramuscular, and intracapsular locations. Further, the use of either PDGFR\u03b1 or scleraxis (Scx) reporter mice demonstrated that both cell types gave rise to periarticular HO in this model. In summary, acetabular reaming reproducibly induces periarticular HO in the mouse reproducing human disease, and with defined mesenchymal cellular contributors similar to other experimental HO models. This protocol may be used in the future for further detailing of the cellular and molecular mediators of post-surgical HO, as well as the screening of new therapies.<\/jats:p>","DOI":"10.1093\/stcltm\/szac042","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:14:19Z","timestamp":1656332059000},"page":"876-888","source":"Crossref","is-referenced-by-count":6,"title":["Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-6654","authenticated-orcid":false,"given":"Stefano","family":"Negri","sequence":"first","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"},{"name":"Orthopaedic and Trauma Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology of the University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masnsen","family":"Cherief","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-3413","authenticated-orcid":false,"given":"Ginny Ching-Yun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Joel","family":"Tower","sequence":"additional","affiliation":[{"name":"Center for Organogenesis Research and Trauma, University of Texas Southwestern , Dallas, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Presson","sequence":"additional","affiliation":[{"name":"Orthopaedic and Trauma Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology of the University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Levi","sequence":"additional","affiliation":[{"name":"Center for Organogenesis Research and Trauma, University of Texas Southwestern , Dallas, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron W","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"issue":"117","key":"2022082317230962300_CIT0001","first-page":"209","article-title":"Heterotopic bone formation after total hip arthroplasty","author":"Riegler","year":"1976","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"2022082317230962300_CIT0002","doi-asserted-by":"crossref","first-page":"e10172","DOI":"10.1002\/jbm4.10172","article-title":"Heterotopic ossification: a comprehensive review","volume":"3","author":"Meyers","year":"2019","journal-title":"JBMR Plus."},{"issue":"3","key":"2022082317230962300_CIT0003","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1073\/pnas.1515397113","article-title":"Inhibition of Hif1alpha prevents both trauma-induced and genetic heterotopic ossification","volume":"113","author":"Agarwal","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2022082317230962300_CIT0004","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/stem.2515","article-title":"Scleraxis-lineage cells contribute to ectopic bone formation in muscle and tendon","volume":"35","author":"Agarwal","year":"2017","journal-title":"Stem Cells"},{"issue":"11","key":"2022082317230962300_CIT0005","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.ajpath.2018.07.014","article-title":"Characterizing the circulating cell populations in traumatic heterotopic ossification","volume":"188","author":"Loder","year":"2018","journal-title":"Am J Pathol"},{"issue":"366","key":"2022082317230962300_CIT0006","doi-asserted-by":"crossref","first-page":"366ra163","DOI":"10.1126\/scitranslmed.aaf1090","article-title":"Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification","volume":"8","author":"Dey","year":"2016","journal-title":"Sci Transl Med"},{"issue":"2","key":"2022082317230962300_CIT0007","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2015.02.011","article-title":"BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints","volume":"400","author":"Agarwal","year":"2015","journal-title":"Dev Biol"},{"issue":"3","key":"2022082317230962300_CIT0008","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/stem.2515","article-title":"Scleraxis-lineage cells contribute to ectopic bone formation in muscle and tendon","volume":"35","author":"Agarwal","year":"2017","journal-title":"Stem Cells"},{"issue":"1","key":"2022082317230962300_CIT0009","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bone.2012.12.008","article-title":"Glast-expressing progenitor cells contribute to heterotopic ossification","volume":"53","author":"Kan","year":"2013","journal-title":"Bone."},{"key":"2022082317230962300_CIT0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.humpath.2017.03.005","article-title":"Vascular patterning in human heterotopic ossification","volume":"63","author":"Cocks","year":"2017","journal-title":"Hum Pathol"},{"issue":"8","key":"2022082317230962300_CIT0011","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2106\/00004623-197355080-00006","article-title":"Ectopic ossification following total hip replacement. Incidence and a method of classification","volume":"55","author":"Brooker","year":"1973","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"2022082317230962300_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12306-010-0091-6","article-title":"Heterotopic ossification after total hip arthroplasty: our experience","volume":"95","author":"Spinarelli","year":"2011","journal-title":"Musculoskelet Surg"},{"issue":"4","key":"2022082317230962300_CIT0013","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/0363546511434285","article-title":"The incidence of heterotopic ossification after hip arthroscopy","volume":"40","author":"Bedi","year":"2012","journal-title":"Am J Sports Med"},{"key":"2022082317230962300_CIT0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/293528","article-title":"Incidence of heterotopic ossification after surface and conventional total hip arthroplasty: a comparative study using anterolateral approach and indomethacin prophylaxis","volume":"2013","author":"Regis","year":"2013","journal-title":"Biomed Res Int"},{"issue":"5","key":"2022082317230962300_CIT0015","doi-asserted-by":"crossref","first-page":"e1742","DOI":"10.7205\/MILMED-D-16-00350","article-title":"The impact of cigarette smoking on the formation of heterotopic ossification among service members with a traumatic amputation","volume":"182","author":"Lewis","year":"2017","journal-title":"Mil Med"},{"issue":"1","key":"2022082317230962300_CIT0016","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12891-017-1391-x","article-title":"Influence of surgical approach on heterotopic ossification after total hip arthroplasty\u2014is minimal invasive better? A case control study","volume":"18","author":"Hurlimann","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"issue":"188","key":"2022082317230962300_CIT0017","first-page":"160","article-title":"Comparison of heterotopic bone after anterolateral, transtrochanteric, and posterior approaches for total hip arthroplasty","author":"Morrey","year":"1984","journal-title":"Clin Orthop Relat Res"},{"issue":"9","key":"2022082317230962300_CIT0018","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.arth.2014.04.027","article-title":"Incidence of heterotopic ossification in direct anterior total hip arthroplasty: a retrospective radiographic review","volume":"29","author":"Tippets","year":"2014","journal-title":"J Arthroplasty"},{"issue":"9","key":"2022082317230962300_CIT0019","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0020-1383(01)00194-2","article-title":"Gluteus minimus necrotic muscle debridement diminishes heterotopic ossification after acetabular fracture fixation","volume":"33","author":"Rath","year":"2002","journal-title":"Injury"},{"issue":"303","key":"2022082317230962300_CIT0020","doi-asserted-by":"crossref","first-page":"303ra137","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci Transl Med"},{"issue":"1","key":"2022082317230962300_CIT0021","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41467-018-02872-2","article-title":"Activin-dependent signaling in fibro\/adipogenic progenitors causes fibrodysplasia ossificans progressiva","volume":"9","author":"Lees-Shepard","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"2022082317230962300_CIT0022","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bone.2013.01.002","article-title":"Early detection of burn induced heterotopic ossification using transcutaneous Raman spectroscopy","volume":"54","author":"Peterson","year":"2013","journal-title":"Bone"},{"issue":"6","key":"2022082317230962300_CIT0023","doi-asserted-by":"crossref","first-page":"510","DOI":"10.5966\/sctm.2012-0002","article-title":"Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering","volume":"1","author":"James","year":"2012","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"2022082317230962300_CIT0024","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jor.22500","article-title":"A novel mouse model of trauma induced heterotopic ossification","volume":"32","author":"Liu","year":"2014","journal-title":"J Orthop Res"},{"issue":"2","key":"2022082317230962300_CIT0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.4519","article-title":"Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle","volume":"236","author":"Genet","year":"2015","journal-title":"J Pathol"},{"issue":"2","key":"2022082317230962300_CIT0026","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/stem.3108","article-title":"PDGFRalpha marks distinct perivascular populations with different osteogenic potential within adipose tissue","volume":"38","author":"Wang","year":"2020","journal-title":"Stem Cells"},{"issue":"9","key":"2022082317230962300_CIT0027","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.ajpath.2020.05.017","article-title":"Perivascular fibro-adipogenic progenitor tracing during post-traumatic osteoarthritis","volume":"190","author":"Sono","year":"2020","journal-title":"Am J Pathol"},{"issue":"4","key":"2022082317230962300_CIT0028","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuron.2010.09.009","article-title":"NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration","volume":"68","author":"Kang","year":"2010","journal-title":"Neuron"},{"issue":"11","key":"2022082317230962300_CIT0029","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/jor.24648","article-title":"Platelet-derived growth factor receptor-beta (PDGFRbeta) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis","volume":"38","author":"Sono","year":"2020","journal-title":"J Orthop Res"},{"issue":"6","key":"2022082317230962300_CIT0030","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/dvdy.21179","article-title":"Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene","volume":"236","author":"Pryce","year":"2007","journal-title":"Dev Dyn"},{"issue":"12","key":"2022082317230962300_CIT0031","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/sctm.20-0152","article-title":"Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation","volume":"9","author":"Negri","year":"2020","journal-title":"Stem Cells Transl Med"},{"issue":"4","key":"2022082317230962300_CIT0032","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/sctm.20-0293","article-title":"Systemic DKK1 neutralization enhances human adipose-derived stem cell mediated bone repair","volume":"10","author":"Negri","year":"2021","journal-title":"Stem Cells Transl Med"},{"issue":"5","key":"2022082317230962300_CIT0033","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/jbmr.1562","article-title":"Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification","volume":"27","author":"Wosczyna","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2022082317230962300_CIT0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/293528","article-title":"Incidence of heterotopic ossification after surface and conventional total hip arthroplasty: a comparative study using anterolateral approach and indomethacin prophylaxis","volume":"2013","author":"Regis","year":"2013","journal-title":"Biomed Res Int"},{"key":"2022082317230962300_CIT0035","doi-asserted-by":"crossref","first-page":"45238","DOI":"10.1038\/srep45238","article-title":"Novel model of tendon regeneration reveals distinct cell mechanisms underlying regenerative and fibrotic tendon healing","volume":"7","author":"Howell","year":"2017","journal-title":"Sci Rep"},{"issue":"102","key":"2022082317230962300_CIT0036","first-page":"e52880","article-title":"Direct mouse trauma\/burn model of heterotopic ossification","author":"Peterson","year":"2015","journal-title":"J Vis Exp"},{"issue":"2","key":"2022082317230962300_CIT0037","doi-asserted-by":"crossref","first-page":"e12107","DOI":"10.2196\/12107","article-title":"System setup to deliver air impact forces to a sheep limb: preparation for model development of blast-related heterotopic ossification","volume":"8","author":"Williams","year":"2019","journal-title":"JMIR Res Protoc"},{"issue":"8","key":"2022082317230962300_CIT0038","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1302\/2046-3758.18.2000102","article-title":"Blast injuries and heterotopic ossification","volume":"1","author":"Alfieri","year":"2012","journal-title":"Bone Joint Res"},{"issue":"5","key":"2022082317230962300_CIT0039","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.H.00792","article-title":"Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors","volume":"91","author":"Forsberg","year":"2009","journal-title":"J Bone Joint Surg Am"},{"key":"2022082317230962300_CIT0040","first-page":"S116","article-title":"Comparison of development of heterotopic ossification in injured US and UK armed services personnel with combat-related amputations: preliminary findings and hypotheses regarding causality","volume":"69","author":"Brown","year":"2010","journal-title":"J Trauma"},{"issue":"5","key":"2022082317230962300_CIT0041","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/jbmr.1562","article-title":"Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification","volume":"27","author":"Wosczyna","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2022082317230962300_CIT0042","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1172\/JCI136142","article-title":"Immobilization after injury alters extracellular matrix and stem cell fate","volume":"130","author":"Huber","year":"2020","journal-title":"J Clin Invest"},{"issue":"1","key":"2022082317230962300_CIT0043","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-021-00176-8","article-title":"PDGFRalpha reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair","volume":"10","author":"Xu","year":"2022","journal-title":"Bone Res"},{"issue":"6","key":"2022082317230962300_CIT0044","doi-asserted-by":"crossref","first-page":"745","DOI":"10.5966\/sctm.2015-0082","article-title":"Influence of bone and muscle injuries on the osteogenic potential of muscle progenitors: contribution of tissue environment to heterotopic ossification","volume":"5","author":"Molligan","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"2022082317230962300_CIT0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bone.2017.06.014","article-title":"Gli1-labeled adult mesenchymal stem\/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification","volume":"109","author":"Kan","year":"2018","journal-title":"Bone."},{"issue":"4","key":"2022082317230962300_CIT0046","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/sctm.16-0347","article-title":"Progenitors in peripheral nerves launch heterotopic ossification","volume":"6","author":"Olmsted-Davis","year":"2017","journal-title":"Stem Cells Transl Med"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/11\/8\/876\/45503955\/szac042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/11\/8\/876\/45503955\/szac042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T17:24:20Z","timestamp":1661275460000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/11\/8\/876\/6618514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,6,27]]},"published-print":{"date-parts":[[2022,8,23]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szac042","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,6,27]]}}}