{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:37:14Z","timestamp":1793072234613,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1A2C1007789"],"award-info":[{"award-number":["NRF-2020R1A2C1007789"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1C1C102368"],"award-info":[{"award-number":["NRF-2022R1C1C102368"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["NRF-2018R1A5A2020732"],"award-info":[{"award-number":["NRF-2018R1A5A2020732"]}]},{"name":"Korean Fund for Regenerative Medicine"},{"name":"Ministry of Science and ICT, the Ministry of Health & Welfare","award":["21D0804L1"],"award-info":[{"award-number":["21D0804L1"]}]},{"name":"Ministry of Science and ICT, the Ministry of Health & Welfare","award":["RS-2022-00040242"],"award-info":[{"award-number":["RS-2022-00040242"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There are still no definite treatment modalities for interstitial cystitis (IC). Meanwhile, stem cell therapy is rising as potential alternative for various chronic diseases. This study aimed to investigate the safety of the clinical-grade mesenchymal stem cells (MSCs) derived from human embryonic stem cells (hESCs), code name MR-MC-01 (SNU42-MMSCs), in IC patients. Three female IC patients with (1) symptom duration &amp;gt;6 months, (2) visual pain analog scale (VAS) \u22654, and (3) one or two Hunner lesions &amp;lt;2 cm in-office cystoscopy within 1 month were included. Under general anesthesia, participants received cystoscopic submucosal injection of SNU42-MMSCs (2.0 \u00d7 107\/5 mL) at the center or margin of Hunner lesions and other parts of the bladder wall except trigone with each injection volume of 1 mL. Follow-up was 1, 3, 6, 9, and 12 months postoperatively. Patients underwent scheduled follow-ups, and symptoms were evaluated with validated questionnaires at each visit. No SNU42-MMSCs-related adverse events including immune reaction and abnormalities on laboratory tests and image examinations were reported up to 12-month follow-up. VAS pain was temporarily improved in all subjects. No de novo Hunner lesions were observed and one lesion of the first subject was not identifiable on 12-month cystoscopy. This study reports the first clinical application of transurethral hESC-derived MSC injection in three patients with IC. hESC-based therapeutics was safe and proved to have potential therapeutic efficacy in IC patients. Stem cell therapy could be a potential therapeutic option for treating IC.<\/jats:p>","DOI":"10.1093\/stcltm\/szac065","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:37:25Z","timestamp":1661330245000},"page":"1010-1020","source":"Crossref","is-referenced-by-count":41,"title":["Safety of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells for Treating Interstitial Cystitis: A Phase I Study"],"prefix":"10.1093","volume":"11","author":[{"given":"Jung Hyun","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Urology, Ewha Womans University, Mokdong Hospital , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae-Min","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"},{"name":"Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Yeul","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"},{"name":"Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Reum","family":"Kang","sequence":"additional","affiliation":[{"name":"Mirae Cell Bio Co., Ltd. , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Min","family":"Shin","sequence":"additional","affiliation":[{"name":"Mirae Cell Bio Co., Ltd. , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Sung","family":"Hong","sequence":"additional","affiliation":[{"name":"Mirae Cell Bio Co., Ltd. , Seoul , Korea"},{"name":"Department of Stem Cell Biology, School of Medicine, Konkuk University , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Mirae Cell Bio Co., Ltd. , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Min","family":"Chung","sequence":"additional","affiliation":[{"name":"Mirae Cell Bio Co., Ltd. , Seoul , Korea"},{"name":"Department of Stem Cell Biology, School of Medicine, Konkuk University , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-5750","authenticated-orcid":false,"given":"Dong-Myung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-4751","authenticated-orcid":false,"given":"Myung-Soo","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"2022102113281263200_CIT0001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/JU.0000000000002756","article-title":"Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome","volume":"208","author":"Clemens","year":"2022","journal-title":"J Urol"},{"key":"2022102113281263200_CIT0002","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/iju.14234","article-title":"Clinical guidelines for interstitial cystitis\/bladder pain 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