{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:57:31Z","timestamp":1777276651217,"version":"3.51.4"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["DC2021-120817-I00"],"award-info":[{"award-number":["DC2021-120817-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health of the Government of Catalonia","award":["SLT011\/18\/00006"],"award-info":[{"award-number":["SLT011\/18\/00006"]}]},{"name":"Spanish Ministry of Economy, Industry, and Competitiveness","award":["PID2020-15591RB-100"],"award-info":[{"award-number":["PID2020-15591RB-100"]}]},{"name":"La Marato\u0301 de TV3","award":["202001-32"],"award-info":[{"award-number":["202001-32"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya for institutional support","award":["2021 FI_B2 00188"],"award-info":[{"award-number":["2021 FI_B2 00188"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several decades have passed since the generation of the first embryonic stem cell (ESC) lines both in mice and in humans. Since then, stem cell biologists have tried to understand their potential biological and clinical uses for their implementation in regenerative medicine. The hematopoietic field was a pioneer in establishing the potential use for the development of blood cell products and clinical applications; however, early expectations have been truncated by the difficulty in generating bonafide hematopoietic stem cells (HSCs). Despite some progress in understanding the origin of HSCs during embryonic development, the reproduction of this process in vitro is still not possible, but the knowledge acquired in the embryo is slowly being implemented for mouse and human pluripotent stem cells (PSCs). In contrast, ESC-derived hematopoietic cells may recapitulate some leukemic transformation processes when exposed to oncogenic drivers. This would be especially useful to model prenatal leukemia development or other leukemia-predisposing syndromes, which are difficult to study. In this review, we will review the state of the art of the use of PSCs as a model for hematopoietic and leukemia development.<\/jats:p>","DOI":"10.1093\/stcltm\/szac071","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T15:40:31Z","timestamp":1666366831000},"page":"1123-1134","source":"Crossref","is-referenced-by-count":8,"title":["Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-6899","authenticated-orcid":false,"given":"Anna","family":"Bigas","sequence":"first","affiliation":[{"name":"Program in Cancer Research, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), CIBERONC , Barcelona , Spain"},{"name":"Josep Carreras Leukemia Research Institute (IJC) , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Gal\u00e1n Palma","sequence":"additional","affiliation":[{"name":"Program in Cancer Research, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), CIBERONC , Barcelona , Spain"},{"name":"Josep Carreras Leukemia Research Institute (IJC) , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri M","family":"Kartha","sequence":"additional","affiliation":[{"name":"Program in Cancer Research, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), CIBERONC , Barcelona , Spain"},{"name":"Josep Carreras Leukemia Research Institute (IJC) , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Giorgetti","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Institut d\u2019Investigacio\u0301 Biome\u0300dica de Bellvitge (IDIBELL) , Barcelona , Spain"},{"name":"Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona 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