{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:04Z","timestamp":1790661064681,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20bk0104114"],"award-info":[{"award-number":["JP20bk0104114"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19bm0204001"],"award-info":[{"award-number":["JP19bm0204001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP15bm0204001"],"award-info":[{"award-number":["JP15bm0204001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem\/progenitor cells (hiPSC-NS\/PCs) is a new therapeutic strategy for spinal cord injury (SCI). Preclinical studies have demonstrated the efficacy of hiPSC-NS\/PCs transplantation in the subacute phase of SCI. However, locomotor recovery secondary to hiPSC-NS\/PCs transplantation is limited in the chronic phase, suggesting that additional treatment, including rehabilitative training, is required to ensure recovery. The therapeutic potential of hiPSC-NS\/PCs that qualify for clinical application is yet to be fully delineated. Therefore, in this study, we investigated the therapeutic effect of the combined therapy of clinical-grade hiPSC-NS\/PCs transplantation and rehabilitative training that could produce synergistic effects in a rodent model of chronic SCI. Our findings indicated that rehabilitative training promoted the survival rate and neuronal differentiation of transplanted hiPSC-NS\/PCs. The combination therapy was able to enhance the expressions of the BDNF and NT-3 proteins in the spinal cord tissue. Moreover, rehabilitation promoted neuronal activity and increased 5-HT-positive fibers at the lumbar enlargement. Consequently, the combination therapy significantly improved motor functions. The findings of this study suggest that the combined therapy of hiPSC-NS\/PCs transplantation and rehabilitative training has the potential to promote functional recovery even when initiated during chronic SCI.<\/jats:p>","DOI":"10.1093\/stcltm\/szac089","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T08:13:36Z","timestamp":1673943216000},"page":"83-96","source":"Crossref","is-referenced-by-count":31,"title":["Rehabilitative Training Enhances Therapeutic Effect of Human iPSC-Derived Neural Stem\/Progenitor Cells Transplantation in Chronic Spinal Cord Injury"],"prefix":"10.1093","volume":"12","author":[{"given":"Takahiro","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Keio University School of Medicine , Shinjuku-ku, Tokyo , Japan"},{"name":"Department of Physiology, Keio University School of Medicine , Shinjuku-ku, Tokyo , 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