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Our work revealed that 3 fibrotic progression markers (Vimentin, COL5A2, and COL1A1) were significantly increased in the endometrium of IUA patients. Mesenchymal stem cell\u2013derived exosomes (EXOs) have been recently revealed as a cell-free therapy for fibrosis diseases. Nevertheless, the application of EXOs is restricted by the short residency duration in the target tissue. To overcome this limitation, herein, we reported an exosome\u2013based regimen (EXOs-HP) that thermosensitive poloxamer hydrogel possessed the ability to efficiently promote the residency duration of EXOs in the uterine cavity. By downregulating fibrotic progression markers (Vimentin, COL5A2, and COL1A1), EXOs-HP could significantly restore the function and structure of the injured endometrium in the IUA model. Our work provides the theoretical and experimental foundation of EXOs-HP in treating IUA, highlighting the clinical potential of topical EXOs-HP delivery system in IUA patients.<\/jats:p>","DOI":"10.1093\/stcltm\/szad007","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T16:39:55Z","timestamp":1676133595000},"page":"154-168","source":"Crossref","is-referenced-by-count":53,"title":["Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers"],"prefix":"10.1093","volume":"12","author":[{"given":"Yifeng","family":"Lin","sequence":"first","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People\u2019s Republic of 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Laboratory of Women\u2019s Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Chi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , People\u2019s Republic of China"},{"name":"Dr Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University , Hangzhou , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Women\u2019s Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Women\u2019s Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Women\u2019s Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Women\u2019s Reproductive Health of Zhejiang Province and Department of 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