{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:19Z","timestamp":1792167739505,"version":"4.4.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IOC Medical and Scientific Research","award":["2020-002"],"award-info":[{"award-number":["2020-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate whether the natural progression rate of retinitis pigmentosa (RP) can be decreased with subtenon Wharton\u2019s jelly-derived mesenchymal stem cell (WJ-MSC) application alone or combination with Magnovision.<\/jats:p>\n               <jats:p>The study included prospective analysis of 130 eyes of 80 retinitis pigmentosa patients with a 36-month follow-up duration. Patients constitute 4 groups with similar demographic characteristics. The subtenon WJ-MSC-only group consisted of 34 eyes of 32 RP patients as Group 1; the Magnovision-only group consisted of 32 eyes of 16 RP patients as Group 2; the combined management group consisted of 32 eyes of 16 RP patients who received combined WJ-MSC and Magnovision as Group 3; the natural course (control) group consisted of 32 eyes of 16 RP patients who did not receive any treatment were classified as Group 4. Fundus autofluorescence surface area (FAF-field), horizontal and vertical ellipsoid zone width (EZW), fundus perimetry deviation index (FPDI), full-field electroretinography magnitude (ERG-m), and best corrected visual acuity (BCVA) changes were compared within and between groups after 36 months follow up period.<\/jats:p>\n               <jats:p>FAF-field delta changes were detected 0.39 mm2 in Group 1, 1.50 mm2 in Group 2, 0.07 mm2 in Group 3 and 12.04 mm2 in Group 4 (\u0394p 4\u2005&amp;gt;\u20052\u2005&amp;gt;\u20051\u2005&amp;gt;\u20053). Horizontal EZW, Vertical EZW, BCVA, and FPDI delta changes were detected \u0394p 4\u2005&amp;gt;\u20051,2\u2005&amp;gt;\u20053. ERG-m delta changes were detected \u0394p 3\u2005&amp;gt;\u20051,2,4.<\/jats:p>\n               <jats:p>Retinitis pigmentosa characterized by progressive loss of photoreceptors eventually leading to total blindness. The combination of WJ-MSC and Magnovision can significantly slow the progression of the disease in comparison to natural progression rate for 3 years in appropriate cases.<\/jats:p>\n               <jats:p>Trial Registration: ClinicalTrials.gov, NCT05800301.<\/jats:p>","DOI":"10.1093\/stcltm\/szad051","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T19:20:42Z","timestamp":1694805642000},"page":"631-650","source":"Crossref","is-referenced-by-count":11,"title":["Management of Retinitis Pigmentosa Via Wharton\u2019s Jelly-Derived Mesenchymal Stem Cells or Combination With Magnovision: 3-Year Prospective Results"],"prefix":"10.1093","volume":"12","author":[{"given":"Emin","family":"Ozmert","sequence":"first","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Ophthalmology , Ankara , T\u00fcrkiye"},{"name":"Ankara University Technopolis, Bioretina Eye Clinic , Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-8083","authenticated-orcid":false,"given":"Umut","family":"Arslan","sequence":"additional","affiliation":[{"name":"Ankara University Technopolis, Bioretina Eye Clinic , Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"2023100513380639100_CIT0001","first-page":"4883","article-title":"Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies","volume-title":"Int J Mol Sci","author":"Liu","year":"2022"},{"key":"2023100513380639100_CIT0002","first-page":"263","article-title":"Retinitis pigmentosa: review of current treatment","volume-title":"Int Ophthalmol Clin","author":"Wang","year":"2019"},{"key":"2023100513380639100_CIT0003","first-page":"265","article-title":"Retinitis pigmentosa: progress and perspective","volume-title":"Asia Pac J 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