{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:52:55Z","timestamp":1780977175322,"version":"3.54.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Various preclinical stroke models have demonstrated the neuroprotective effects of extracellular vesicles (EVs) obtained from several types of cells, including neurons, astrocytes, microglia, neuronal progenitor cells, bone marrow stem cells, and mesenchymal stem cells. EVs interfere with key mechanisms in stroke pathophysiology such as cell death, neuroinflammation, autophagy, and angiogenesis. The mode of action and efficacy depend on the specific EV content, including miRNAs, proteins, and lipids, which can be modified through (I) bioengineering methods, (II) choice of source cells, and (III) modification of the source cell environment. Indeed, modifying the environment by preconditioning the EV-secreting cells with oxygen-glucose deprivation or medium modification revealed superior neuroprotective effects in stroke models. Although the concept of preconditioned EVs is relatively novel, it holds promise for the future treatment of ischemic stroke. Here, we give a brief overview about the main mechanisms of EV-induced neuroprotection and discuss the current status of preconditioning concepts for EV-treatment of ischemic stroke.<\/jats:p>","DOI":"10.1093\/stcltm\/szad055","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:32:14Z","timestamp":1694467934000},"page":"707-713","source":"Crossref","is-referenced-by-count":8,"title":["Preconditioning Concepts for the Therapeutic Use of Extracellular Vesicles Against Stroke"],"prefix":"10.1093","volume":"12","author":[{"given":"Matteo","family":"Haupt","sequence":"first","affiliation":[{"name":"Deparment of Neurology, University of G\u00f6ttingen Medical School , G\u00f6ttingen , Lower Saxony, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T","family":"Gerner","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, University Hospital Giessen , Giessen, Hesse , Germany"},{"name":"Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen , Marburg, Hesse , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen B","family":"Huttner","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, University Hospital Giessen , Giessen, Hesse , Germany"},{"name":"Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen , Marburg, Hesse , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-9211","authenticated-orcid":false,"given":"Thorsten R","family":"Doeppner","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, University of G\u00f6ttingen Medical School , G\u00f6ttingen , Lower Saxony, Germany"},{"name":"Deparment of Neurology, University Hospital Giessen , Giessen, Hesse , Germany"},{"name":"Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig 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