{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:52:44Z","timestamp":1782888764018,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["NMRPG8L0081"],"award-info":[{"award-number":["NMRPG8L0081"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study tested the hypothesis that combined ceftriaxone (Cef) and human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) was better than either therapy for alleviating acute septic arthritis (ASA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Adult-male C57BL\/6 mice were categorized into control group (Clt), group A (ASA only), group B [ASA\u2005+\u2005Cef (5 mg\/kg, IM per day, at days 2 to 16 after ASA induction)], group C [ASA\u2005+\u2005HUCDMSCs (5\u2005\u00d7\u2005105 per mice at days 2, 3, 4 after ASA induction)], and group D (ASA\u2005+\u2005Cef\u2005+\u2005HUCDMSCs). Animals were euthanized by day 28. The result demonstrated that the body weight was significantly lower, whereas the ratio of kidney or spleen weight to WB, circulatory WBC count, bacterial colony-formation-unit from circulatory\/kidney extraction were significantly higher in group A than in other groups (all P\u2005&amp;lt;\u2005.001). The proinflammatory cytokines (IL-6\/TNF-\u03b1) of knee joint fluid were lowest in Clt and significantly and progressively reduced from groups A to D, whereas the circulatory levels of these 2 parameters at the time points of days 3\/7\/28 exhibited an identical pattern as knee joint fluid among the groups (all P-value\u2005&amp;lt;\u2005.0001). The scores of vertebral-bone destructions\/inflamed synovium were lowest in Clt, highest in group A, significantly higher in group C than in groups B\/D, and significantly higher in group C than in group D (all P\u2005&amp;lt;\u2005.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Combined antibiotics and Cef and HUCDMSCs was superior to just one therapy for suppressing circulatory and tissue levels of inflammation and knee joint destruction in ASA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/stcltm\/szae034","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:16:10Z","timestamp":1718781370000},"page":"724-737","source":"Crossref","is-referenced-by-count":2,"title":["Synergic effect of combined xenogeneic mesenchymal stem cells and ceftriaxone on acute septic arthritis"],"prefix":"10.1093","volume":"13","author":[{"given":"Pei-Hsun","family":"Sung","sequence":"first","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Cardiology, Department of Internal Medicine, , Kaohsiung 833401, Taiwan, ROC"},{"name":"Kaohsiung Chang Gung Memorial Hospital Kaohsiung Center for Shockwave Medicine and Tissue Engineering, , Kaohsiung 833401, Taiwan, ROC"},{"name":"Kaohsiung Chang Gung Memorial Hospital Kaohsiung Institute for Translational Research in Biomedicine, 833401, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Cheng","family":"Yin","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Orthopedics, , 833401 Kaohsiung, Taiwan, ROC"},{"name":"Cheng Shiu University Center for General Education, , Kaohsiung 833301 , Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Y","family":"Chiang","sequence":"additional","affiliation":[{"name":"National Sun Yat-Sen University Department of Computer Science and Engineering, , Kaohsiung 804201, Taiwan, ROC"},{"name":"Kaohsiung Medical University Department of Healthcare Administration and Medical Informatics, , Kaohsiung 807378, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Divisions of General Medicine, , Kaohsiung 833401 , Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ruei","family":"Huang","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Cardiology, Department of Internal Medicine, , Kaohsiung 833401, Taiwan, 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