{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:09:55Z","timestamp":1792004995087,"version":"4.4.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Cathedra University of Granada-Ziacom"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Periodontitis and peri-implantitis are inflammatory diseases of infectious etiology that lead to the destruction of the supporting tissues located around teeth or implants. Although both pathologies share several characteristics, it is also known that they show important differences which could be due to the release of particles and metal ions from the implant surface. The activation of the inflammasome pathway is one of the main triggers of the inflammatory process. The inflammatory process in patients who suffer periodontitis or peri-implantitis has been mainly studied on cells of the immune system; however, it is also important to consider other cell types with high relevance in the regulation of the inflammatory response. In that context, mesenchymal stromal cells (MSCs) play an essential role in the regulation of inflammation due to their ability to modulate the immune response. This study shows that the induction of NLRP3 and absent in melanoma 2 (AIM2) inflammasome pathways mediated by bacterial components increases the secretion of active IL-1\u03b2 and the pyroptotic process on human alveolar bone-derived mesenchymal stromal cells (hABSCs). Interestingly, when bacterial components are combined with titanium ions, NLRP3 expression is further increased while AIM2 expression is reduced. Furthermore, decrease of NLRP3 or AIM2 expression in hABSCs partially reverses the negative effect observed on the progression of the inflammatory process as well as on cell survival. In summary, our data suggest that the progression of the inflammatory process in peri-implantitis could be more acute due to the combined action of organic and inorganic components.<\/jats:p>","DOI":"10.1093\/stcltm\/szae042","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T01:48:24Z","timestamp":1721180904000},"page":"826-841","source":"Crossref","is-referenced-by-count":16,"title":["NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1\u03b2 in alveolar bone-derived MSCs"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-1469","authenticated-orcid":false,"given":"Ana Bel\u00e9n","family":"Carrillo-G\u00e1lvez","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Zurita","sequence":"additional","affiliation":[{"name":"Department of Genetics and Institute of Biotechnology, University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Guerra-Valverde","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Clinical Medicine and Public Health, University of Granada PhD Program in , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Aguilar-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Pfizer\/University of Granada\/Andalusian Regional Government PTS Granada GENYO, Centre for Genomics and Oncological Research, , 18016 Granada, Spain"},{"name":"Department of Medicinal and Organic Chemistry and Excellence Research Unit of Chemistry Applied to Bio-Medicine and the Environment, Faculty of Pharmacy, University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo","family":"Abril-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Padial-Molina","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allinson","family":"Olaechea","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Clinical Medicine and Public Health, University of Granada PhD Program in , 18071 Granada , Spain"},{"name":"Pfizer\/University of Granada\/Andalusian Regional Government PTS Granada GENYO, Centre for Genomics and Oncological Research, , 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natividad","family":"Mart\u00edn-Morales","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Biomedicine, University of Granada PhD Program in , 18071 Granada , Spain"},{"name":"Department of Pathology, School of Medicine, University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Pfizer\/University of Granada\/Andalusian Regional Government PTS Granada GENYO, Centre for Genomics and Oncological Research, , 18016 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada , 18071 Granada , Spain"},{"name":"Excellence Research Unit \u201cModeling Nature\u201d (MNat), University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"O\u2019Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"},{"name":"Department of Pathology, School of Medicine, University of Granada , 18071 Granada , Spain"},{"name":"Institute of Biopathology and Regenerative Medicine (IBIMER, CIBM), University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Galindo-Moreno","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS) de Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"1","key":"2024082619130015100_CIT0001","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Prim"},{"issue":"14","key":"2024082619130015100_CIT0002","doi-asserted-by":"crossref","first-page":"609614","DOI":"10.3389\/fphys.2020.609614","article-title":"Inflammation in periodontal disease: possible link to vascular disease","volume":"11","author":"Paul","year":"2021","journal-title":"Front Physiol"},{"issue":"Suppl 20","key":"2024082619130015100_CIT0003","first-page":"S286","article-title":"Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Berglundh","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"3","key":"2024082619130015100_CIT0004","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.5037\/jomr.2016.7310","article-title":"Microbial profiles and detection techniques in peri-implant diseases: a systematic review","volume":"7","author":"Padial-Molina","year":"2016","journal-title":"J oral Maxillofac Res"},{"issue":"12","key":"2024082619130015100_CIT0005","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/jcpe.13370","article-title":"Cellular expression of DNA damage\/repair and reactive oxygen\/nitrogen species in human periodontitis and peri-implantitis lesions","volume":"47","author":"Dionigi","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"9","key":"2024082619130015100_CIT0006","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/jcm8091501","article-title":"Are oral implants the same as teeth","volume":"8","author":"Albrektsson","year":"2019","journal-title":"J Clin Med"},{"issue":"11","key":"2024082619130015100_CIT0007","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1177\/0022034514551754","article-title":"Composition of human peri-implantitis and periodontitis lesions","volume":"93","author":"Carcuac","year":"2014","journal-title":"J Dent Res"},{"issue":"4","key":"2024082619130015100_CIT0008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jcpe.12535","article-title":"Peri-implantitis - onset and pattern of progression","volume":"43","author":"Derks","year":"2016","journal-title":"J Clin Periodontol"},{"issue":"6","key":"2024082619130015100_CIT0009","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.11607\/jomi.6077","article-title":"Titanium activates the DNA damage response pathway in oral epithelial cells: a pilot study","volume":"32","author":"Su\u00e1rez-L\u00f3pez del Amo","year":"2017","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"1","key":"2024082619130015100_CIT0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/prd.12269","article-title":"Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics","volume":"82","author":"Marchesan","year":"2020","journal-title":"Periodontol 2000"},{"issue":"8","key":"2024082619130015100_CIT0011","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"7237","key":"2024082619130015100_CIT0012","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"issue":"9","key":"2024082619130015100_CIT0013","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.4049\/jimmunol.1102093","article-title":"Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells","volume":"187","author":"Xiang","year":"2011","journal-title":"J Immunol"},{"issue":"SEP","key":"2024082619130015100_CIT0014","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3389\/fimmu.2017.01168","article-title":"Epithelial cell inflammasomes in intestinal immunity and inflammation","volume":"8","author":"Lei-Leston","year":"2017","journal-title":"Front Immunol"},{"issue":"4","key":"2024082619130015100_CIT0015","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2017.02.007","article-title":"NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation","volume":"484","author":"Wang","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2024082619130015100_CIT0016","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1517\/14712598.2010.519333","article-title":"Mesenchymal stem cells: biological properties and clinical applications","volume":"10","author":"Garc\u00eda-G\u00f3amez","year":"2010","journal-title":"Expert Opin Biol Ther"},{"issue":"4","key":"2024082619130015100_CIT0017","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s10753-020-01206-z","article-title":"Titanium ions play a synergistic role in the activation of NLRP3 inflammasome in jurkat T cells","volume":"43","author":"Li","year":"2020","journal-title":"Inflammation"},{"issue":"5","key":"2024082619130015100_CIT0018","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1007\/s10753-022-01672-7","article-title":"Ti Ions Induce IL-1\u03b2 release by activation of the NLRP3 inflammasome in a human macrophage cell line","volume":"45","author":"Pettersson","year":"2022","journal-title":"Inflammation"},{"issue":"9","key":"2024082619130015100_CIT0019","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3390\/ijms20092171","article-title":"Expression of Musashi-1 during osteogenic differentiation of oral MSC: an in vitro study","volume":"20","author":"Padial-Molina","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"17","key":"2024082619130015100_CIT0020","doi-asserted-by":"crossref","first-page":"37289","DOI":"10.1038\/srep37289","article-title":"Lent-on-plus lentiviral vectors for conditional expression in human stem cells","volume":"6","author":"Benabdellah","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"2024082619130015100_CIT0021","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/sctm.19-0372","article-title":"GARP is a key molecule for mesenchymal stromal cell responses to TGF-\u03b2 and fundamental to control mitochondrial ROS levels","volume":"9","author":"Carrillo-G\u00e1lvez","year":"2020","journal-title":"Stem Cells Transl"},{"issue":"1","key":"2024082619130015100_CIT0022","doi-asserted-by":"crossref","DOI":"10.3892\/wasj.2024.224","article-title":"Comparative analysis of serum titanium levels in patients with healthy dental implants and patients with peri\u2011implantitis: a cross-sectional prospective study","volume":"6","author":"Sharanappa","year":"2024","journal-title":"World Acad Sci J"},{"issue":"4","key":"2024082619130015100_CIT0023","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1164\/rccm.200206-518OC","article-title":"Postlipopolysaccharide oxidative damage of mitochondrial DNA","volume":"167","author":"Suliman","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2024082619130015100_CIT0024","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41392-021-00494-7","article-title":"LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury","volume":"6","author":"Zhan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2024082619130015100_CIT0025","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jcp.21051","article-title":"Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis","volume":"212","author":"Hom","year":"2007","journal-title":"J Cell Physiol"},{"issue":"10","key":"2024082619130015100_CIT0026","doi-asserted-by":"crossref","first-page":"e3074","DOI":"10.1038\/cddis.2017.470","article-title":"NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis"},{"issue":"4","key":"2024082619130015100_CIT0027","first-page":"1113","article-title":"Activation of NLRP3 inflammasome promotes the proliferation and migration of esophageal squamous cell carcinoma","volume":"43","author":"Yu","year":"2020","journal-title":"Oncol Rep"},{"issue":"1","key":"2024082619130015100_CIT0028","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.18632\/aging.202226","article-title":"AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1","volume":"13","author":"Xu","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"2024082619130015100_CIT0029","first-page":"1","article-title":"AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K\/AKT\/mTOR signaling pathway","volume":"25","author":"Zheng","year":"2022","journal-title":"Mol Med Rep"},{"issue":"1","key":"2024082619130015100_CIT0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/23337931.2017.1399270","article-title":"Release of titanium after insertion of dental implants with different surface characteristics \u2013 an ex vivo animal study","volume":"3","author":"Pettersson","year":"2017","journal-title":"Acta Biomater Odontol Scand"},{"issue":"4","key":"2024082619130015100_CIT0031","first-page":"3299","article-title":"N-Acetyl cysteine inhibits the lipopolysaccharide\u2011induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP\/NLRP3\/IL-1\u03b2 signaling pathway","volume":"22","author":"Wang","year":"2020","journal-title":"Mol Med Rep"},{"issue":"1","key":"2024082619130015100_CIT0032","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/jre.12364","article-title":"Titanium ions form particles that activate and execute interleukin-1\u03b2 release from lipopolysaccharide-primed macrophages","volume":"52","author":"Pettersson","year":"2017","journal-title":"J Periodontal Res"},{"issue":"1","key":"2024082619130015100_CIT0033","doi-asserted-by":"crossref","first-page":"e2062","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis"},{"issue":"1","key":"2024082619130015100_CIT0034","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1128\/IAI.00862-13","article-title":"Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection","volume":"82","author":"Park","year":"2014","journal-title":"Infect Immun"},{"key":"2024082619130015100_CIT0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.archoralbio.2017.02.006","article-title":"Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth","volume":"78","author":"Ran","year":"2017","journal-title":"Arch Oral Biol"},{"issue":"6","key":"2024082619130015100_CIT0036","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/JPER.21-0423","article-title":"Biome-microbiome interactions in peri-implantitis: a pilot investigation","volume":"93","author":"Ganesan","year":"2022","journal-title":"J Periodontol"},{"issue":"12","key":"2024082619130015100_CIT0037","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/clr.14174","article-title":"Inflammasomes NLRP3 and AIM2 in peri-implantitis: a cross-sectional study","volume":"34","author":"Galindo-Moreno","year":"2023","journal-title":"Clin Oral Implants Res"},{"issue":"12","key":"2024082619130015100_CIT0038","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/ma12122036","article-title":"Metal nanoparticles released from dental implant surfaces: potential contribution to chronic inflammation and peri-implant bone loss","volume":"12","author":"Bressan","year":"2019","journal-title":"Materials (Basel)"},{"issue":"14","key":"2024082619130015100_CIT0039","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.3390\/app11146353","article-title":"Effect of different titanium dental implant surfaces on human adipose mesenchymal stem cell behavior. an in vitro comparative study","volume":"11","author":"D\u2019Esposito","year":"2021","journal-title":"Appl Sci"},{"issue":"11","key":"2024082619130015100_CIT0040","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J Exp Med"},{"issue":"1-2","key":"2024082619130015100_CIT0041","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","article-title":"Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome","volume":"160","author":"Yan","year":"2015","journal-title":"Cell"},{"issue":"1","key":"2024082619130015100_CIT0042","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/cells9010079","article-title":"Transcriptional suppression of the NLRP3 inflammasome and cytokine release in primary macrophages by low-dose anthracyclines","volume":"9","author":"K\u00f6se-Vogel","year":"2020","journal-title":"Cells"},{"issue":"23","key":"2024082619130015100_CIT0043","doi-asserted-by":"crossref","first-page":"e45396","DOI":"10.7554\/eLife.45396","article-title":"Translation affects mRNA stability in a codon-dependent manner in human cells","volume":"8","author":"Wu","year":"2019","journal-title":"Elife"},{"issue":"1","key":"2024082619130015100_CIT0044","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1038\/s41467-019-12028-5","article-title":"CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation","volume":"10","author":"Tuladhar","year":"2019","journal-title":"Nat Commun"},{"issue":"15","key":"2024082619130015100_CIT0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reth.2019.12.011","article-title":"Mesenchymal stem cell-based tissue regeneration therapies for periodontitis","volume":"14","author":"Ouchi","year":"2020","journal-title":"Regen Ther"},{"issue":"21","key":"2024082619130015100_CIT0046","doi-asserted-by":"crossref","first-page":"13419","DOI":"10.3390\/ijms232113419","article-title":"Impact of oral mesenchymal stem cells applications as a promising therapeutic target in the therapy of periodontal disease","volume":"23","author":"Amato","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2024082619130015100_CIT0047","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jopr.12316","article-title":"Gingival mesenchymal stem cell (GMSC) delivery system based on RGD-coupled alginate hydrogel with antimicrobial properties: a novel treatment modality for peri-implantitis","volume":"25","author":"Diniz","year":"2016","journal-title":"J Prosthodont"},{"issue":"3","key":"2024082619130015100_CIT0048","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ymthe.2022.12.014","article-title":"Modulation of NLRP3 inflammasomes activation contributes to improved survival and function of mesenchymal stromal cell spheroids","volume":"31","author":"Pham","year":"2023","journal-title":"Mol Ther"},{"issue":"6","key":"2024082619130015100_CIT0049","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5483\/BMBRep.2020.53.6.065","article-title":"The activation of NLRP3 inflammasome potentiates the immunomodulatory abilities of mesenchymal stem cells in a murine colitis model","volume":"53","author":"Ahn","year":"2020","journal-title":"BMB Rep"},{"issue":"23","key":"2024082619130015100_CIT0050","doi-asserted-by":"crossref","first-page":"839929","DOI":"10.3389\/fimmu.2022.839929","article-title":"NLRP3 is involved in neutrophil mobilization in experimental periodontitis","volume":"13","author":"Cheat","year":"2022","journal-title":"Front Immunol"},{"key":"2024082619130015100_CIT0051","doi-asserted-by":"crossref","first-page":"103803","DOI":"10.1016\/j.ebiom.2021.103803","article-title":"Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice","volume":"75","author":"Zeng","year":"2022","journal-title":"EBioMedicine"},{"issue":"11","key":"2024082619130015100_CIT0052","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1002\/ijc.31827","article-title":"AIM2 deficiency reduces the development of hepatocellular carcinoma in mice","volume":"143","author":"Mart\u00ednez-Cardona","year":"2018","journal-title":"Int J Cancer"},{"issue":"1","key":"2024082619130015100_CIT0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10020-020-00212-z","article-title":"Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortae and angiotensin-II induced aortic aneurysms","volume":"26","author":"Wortmann","year":"2020","journal-title":"Mol Med"},{"issue":"2","key":"2024082619130015100_CIT0054","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/imm.13427","article-title":"NLRP3 knockout enhances immune infiltration and inflammatory responses and improves survival in a burn sepsis model","volume":"165","author":"Stanojcic","year":"2022","journal-title":"Immunology"},{"issue":"5","key":"2024082619130015100_CIT0055","doi-asserted-by":"crossref","first-page":"e20201796","DOI":"10.1084\/jem.20201796","article-title":"AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis","volume":"218","author":"Ma","year":"2021","journal-title":"J Exp Med"},{"issue":"12","key":"2024082619130015100_CIT0056","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s00125-019-04983-x","article-title":"Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance","volume":"62","author":"Gong","year":"2019","journal-title":"Diabetologia"},{"issue":"2","key":"2024082619130015100_CIT0057","doi-asserted-by":"crossref","first-page":"e12973","DOI":"10.1111\/cpr.12973","article-title":"NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation","volume":"54","author":"Chen","year":"2021","journal-title":"Cell Prolif"},{"issue":"9","key":"2024082619130015100_CIT0058","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/JPER.21-0668","article-title":"Interferon activated gene 204 (Ifi204) protects against bone loss in experimental periodontitis","volume":"93","author":"Swanson","year":"2022","journal-title":"J Periodontol"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/13\/8\/826\/58927133\/szae042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/13\/8\/826\/58927133\/szae042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T19:14:39Z","timestamp":1724699679000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/13\/8\/826\/7715046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,7,16]]},"published-print":{"date-parts":[[2024,8,16]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szae042","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,16]]}}}