{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:41Z","timestamp":1791400601409,"version":"4.3.3"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024838","name":"Samsung Medical Center","doi-asserted-by":"crossref","award":["SMX122081"],"award-info":[{"award-number":["SMX122081"]}],"id":[{"id":"10.13039\/501100024838","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Despite recent advances in neonatal intensive care medicine, neonatal disorders such as (bronchopulmonary dysplasia [BPD], intraventricular hemorrhage [IVH], and hypoxic ischemic encephalopathy [HIE]) remain major causes of death and morbidity in survivors, with few effective treatments being available. Recent preclinical studies have demonstrated the pleiotropic host injury-responsive paracrine protective effects of cell therapy especially with mesenchymal stromal cells (MSCs) against BPD, IVH, and HIE. These findings suggest that MSCs therapy might emerge as a novel therapeutic modality for these currently devastating neonatal disorders with complex multifactorial etiologies. Although early-phase clinical trials suggest their safety and feasibility, their clinical therapeutic benefits have not yet been proven. Therefore, based on currently available preclinical research and clinical trial data, we focus on critical issues that need to be addressed for future successful clinical trials and eventual clinical translation such as selecting the right patient and optimal cell type, route, dose, and timing of MSCs therapy for neonatal disorders such as BPD, HIE, and IVH.<\/jats:p>","DOI":"10.1093\/stcltm\/szae060","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T18:27:27Z","timestamp":1723228047000},"page":"941-948","source":"Crossref","is-referenced-by-count":13,"title":["Improving the future of clinical trials and translation of mesenchymal stromal cell therapies for neonatal disorders"],"prefix":"10.1093","volume":"13","author":[{"given":"Yun Sil","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]},{"name":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University , Seoul ,","place":["Korea"]},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-6623","authenticated-orcid":false,"given":"Misun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se In","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gangnam Cha Hospital, Cha University , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"2024101011101680100_CIT0001","first-page":"33","article-title":"Cell therapy for bronchopulmonary dysplasia: promises and perils","volume":"20","author":"Mobius","year":"2016","journal-title":"Paediatr Respir Rev"},{"issue":"3","key":"2024101011101680100_CIT0002","doi-asserted-by":"crossref","first-page":"151724","DOI":"10.1016\/j.semperi.2023.151724","article-title":"Stem cell therapies for neonatal lung diseases: are we there yet","volume":"47","author":"Thebaud","year":"2023","journal-title":"Semin Perinatol"},{"issue":"4","key":"2024101011101680100_CIT0003","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2174\/1573396314666180911100503","article-title":"The therapeutic potential of stem cells for bronchopulmonary dysplasia: \u201cit\u2019s about time\u201d or \u201cnot so fast?\u201d","volume":"14","author":"Ee","year":"2018","journal-title":"Curr Pediatr Rev"},{"issue":"8","key":"2024101011101680100_CIT0004","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3390\/cells11081275","article-title":"Stem-cell therapy for Bronchopulmonary Dysplasia (BPD) in newborns","volume":"11","author":"Omar","year":"2022","journal-title":"Cells"},{"issue":"12","key":"2024101011101680100_CIT0005","doi-asserted-by":"crossref","first-page":"e0189895","DOI":"10.1371\/journal.pone.0189895","article-title":"Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: a systematic review and meta-analysis of preclinical studies","volume":"12","author":"Archambault","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"2024101011101680100_CIT0006","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.3390\/ijms22063142","article-title":"Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies","volume":"22","author":"Serrenho","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2024101011101680100_CIT0007","doi-asserted-by":"crossref","first-page":"151726","DOI":"10.1016\/j.semperi.2023.151726","article-title":"Stem cells for neonatal brain injury - Lessons from the bench","volume":"47","author":"Ahn","year":"2023","journal-title":"Semin Perinatol"},{"issue":"9","key":"2024101011101680100_CIT0008","first-page":"CD013201","article-title":"Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants","volume":"9","author":"Romantsik","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"2024101011101680100_CIT0009","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jcyt.2018.09.003","article-title":"Off-label mesenchymal stromal cell treatment in two infants with severe bronchopulmonary dysplasia: clinical course and biomarkers profile","volume":"20","author":"Alvarez-Fuente","year":"2018","journal-title":"Cytotherapy"},{"issue":"5","key":"2024101011101680100_CIT0010","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy","volume":"164","author":"Cotten","year":"2014","journal-title":"J Pediatr"},{"issue":"6","key":"2024101011101680100_CIT0011","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1474-4422(22)00117-X","article-title":"Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study","volume":"21","author":"Baak","year":"2022","journal-title":"Lancet Neurol"},{"issue":"10","key":"2024101011101680100_CIT0012","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/stcltm\/szad048","article-title":"Allogeneic cell therapy applications in neonates: a systematic review","volume":"12","author":"Razak","year":"2023","journal-title":"Stem Cells Transl. Med"},{"issue":"2","key":"2024101011101680100_CIT0013","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/stcltm\/szab024","article-title":"Umbilical cord blood and cord tissue-derived cell therapies for neonatal morbidities: current status and future challenges","volume":"11","author":"Zhou","year":"2022","journal-title":"Stem Cells Transl. Med."},{"issue":"9","key":"2024101011101680100_CIT0014","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/sctm.18-0079","article-title":"First-in-human administration of allogeneic amnion cells in premature infants with bronchopulmonary dysplasia: a safety study","volume":"7","author":"Lim","year":"2018","journal-title":"Stem Cells Transl. Med."},{"issue":"8","key":"2024101011101680100_CIT0015","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/sctm.20-0330","article-title":"Stem cells for bronchopulmonary dysplasia in preterm infants: a randomized controlled phase II trial","volume":"10","author":"Ahn","year":"2021","journal-title":"Stem Cells Transl. Med."},{"issue":"5","key":"2024101011101680100_CIT0016","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jpeds.2013.12.011","article-title":"Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial","volume":"164","author":"Chang","year":"2014","journal-title":"J Pediatr"},{"issue":"12","key":"2024101011101680100_CIT0017","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/sctm.17-0219","article-title":"Mesenchymal stem cells for severe intraventricular hemorrhage in preterm infants: phase I dose-escalation clinical trial","volume":"7","author":"Ahn","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"2024101011101680100_CIT0018","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jpeds.2019.02.029","article-title":"Safety of intratracheal administration of human umbilical cord blood derived mesenchymal stromal cells in extremely low birth weight preterm infants","volume":"210","author":"Powell","year":"2019","journal-title":"J Pediatr"},{"issue":"5","key":"2024101011101680100_CIT0019","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"issue":"11","key":"2024101011101680100_CIT0020","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1164\/rccm.200902-0242OC","article-title":"Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease","volume":"180","author":"Aslam","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2024101011101680100_CIT0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0055-8","article-title":"Vascular endothelial growth factor mediates the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles against neonatal hyperoxic lung injury","volume":"50","author":"Ahn","year":"2018","journal-title":"Exp Mol Med"},{"issue":"1-2","key":"2024101011101680100_CIT0022","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/pr.2017.256","article-title":"\u201cGood things come in small packages\u201d: application of exosome-based therapeutics in neonatal lung injury","volume":"83","author":"Willis","year":"2018","journal-title":"Pediatr Res"},{"issue":"1-2","key":"2024101011101680100_CIT0023","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/pr.2017.249","article-title":"Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders","volume":"83","author":"Park","year":"2018","journal-title":"Pediatr Res"},{"issue":"9","key":"2024101011101680100_CIT0024","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/glia.22500","article-title":"How stem cells speak with host immune cells in inflammatory brain diseases","volume":"61","author":"Pluchino","year":"2013","journal-title":"Glia"},{"issue":"5","key":"2024101011101680100_CIT0025","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12015-022-10369-1","article-title":"A brief overview of global trends in MSC-based cell therapy","volume":"18","author":"Jovic","year":"2022","journal-title":"Stem cell reviews and reports"},{"issue":"2","key":"2024101011101680100_CIT0026","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/pharmaceutics14020381","article-title":"Mesenchymal stem\/stromal cells and their paracrine activity\u2014immunomodulation mechanisms and how to influence the therapeutic potential","volume":"14","author":"Alvites","year":"2022","journal-title":"Pharmaceutics"},{"issue":"5","key":"2024101011101680100_CIT0027","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3346\/jkms.2015.30.5.509","article-title":"Stem cell therapy for bronchopulmonary dysplasia: bench to bedside translation","volume":"30","author":"Ahn","year":"2015","journal-title":"J Korean Med Sci"},{"issue":"7","key":"2024101011101680100_CIT0028","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jcyt.2014.02.008","article-title":"Comparative analysis of multilineage properties of mesenchymal stromal cells derived from fetal sources shows an advantage of mesenchymal stromal cells isolated from cord blood in chondrogenic differentiation potential","volume":"16","author":"Pievani","year":"2014","journal-title":"Cytotherapy"},{"issue":"6","key":"2024101011101680100_CIT0029","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14653240310003611","article-title":"Immunomodulatory effects of fetal and adult mesenchymal stem cells","volume":"5","author":"Le Blanc","year":"2003","journal-title":"Cytotherapy"},{"issue":"1","key":"2024101011101680100_CIT0030","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13578-021-00698-y","article-title":"Allogeneic vs. autologous mesenchymal stem\/stromal cells in their medication practice","volume":"11","author":"Li","year":"2021","journal-title":"Cell Biosci"},{"key":"2024101011101680100_CIT0031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.addr.2016.10.001","article-title":"Stem cell therapy clinical research: a regulatory conundrum for academia","volume":"122","author":"Nagpal","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"2024101011101680100_CIT0032","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","article-title":"Challenges and advances in clinical applications of mesenchymal stromal cells","volume":"14","author":"Zhou","year":"2021","journal-title":"J Hematol Oncol"},{"key":"2024101011101680100_CIT0033","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jpeds.2019.05.063","article-title":"Stem cells for bronchopulmonary dysplasia: a promising yet challenging journey lies ahead","volume":"212","author":"Sahoo","year":"2019","journal-title":"J Pediatr"},{"issue":"2","key":"2024101011101680100_CIT0034","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2014.01.013","article-title":"MSC-based product characterization for clinical trials: an FDA perspective","volume":"14","author":"Mendicino","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"3","key":"2024101011101680100_CIT0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jcyt.2020.01.004","article-title":"Improving mesenchymal stem\/stromal cell potency and survival: proceedings from the International Society of Cell Therapy (ISCT) MSC preconference held in May 2018, Palais des Congres de Montreal, Organized by the ISCT MSC Scientific Committee","volume":"22","author":"Nolta","year":"2020","journal-title":"Cytotherapy"},{"key":"2024101011101680100_CIT0036","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ebiom.2015.12.020","article-title":"A clinical indications prediction scale based on TWIST1 for human mesenchymal stem cells","volume":"4","author":"Boregowda","year":"2016","journal-title":"EBioMedicine"},{"issue":"8","key":"2024101011101680100_CIT0037","doi-asserted-by":"crossref","first-page":"e0135574","DOI":"10.1371\/journal.pone.0135574","article-title":"Optimal route for human umbilical cord blood-derived mesenchymal stem cell transplantation to protect against neonatal hyperoxic lung injury: gene expression profiles and histopathology","volume":"10","author":"Sung","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"2024101011101680100_CIT0038","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcyt.2015.03.008","article-title":"Cell type-dependent variation in paracrine potency determines therapeutic efficacy against neonatal hyperoxic lung injury","volume":"17","author":"Ahn","year":"2015","journal-title":"Cytotherapy"},{"issue":"3","key":"2024101011101680100_CIT0039","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1165\/rcmb.2013-0385OC","article-title":"Critical role of vascular endothelial growth factor secreted by mesenchymal stem cells in hyperoxic lung injury","volume":"51","author":"Chang","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"2024101011101680100_CIT0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3727\/096368916X692861","article-title":"Pivotal role of brain-derived neurotrophic factor secreted by mesenchymal stem cells in severe intraventricular hemorrhage in newborn rats","volume":"26","author":"Ahn","year":"2017","journal-title":"Cell Transplant"},{"issue":"21","key":"2024101011101680100_CIT0041","doi-asserted-by":"crossref","first-page":"11395","DOI":"10.3390\/ijms222111395","article-title":"BDNF-Overexpressing Engineered mesenchymal stem cells enhances their therapeutic efficacy against severe neonatal hypoxic ischemic brain injury","volume":"22","author":"Ahn","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2024101011101680100_CIT0042","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/jcm8040533","article-title":"Thrombin preconditioning of extracellular vesicles derived from mesenchymal stem cells accelerates cutaneous wound healing by boosting their biogenesis and enriching cargo content","volume":"8","author":"Sung","year":"2019","journal-title":"J Clin Med"},{"issue":"10","key":"2024101011101680100_CIT0043","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.3390\/ijms20102477","article-title":"Thrombin preconditioning enhances therapeutic efficacy of human wharton\u2019s jelly-derived mesenchymal stem cells in severe neonatal hypoxic ischemic encephalopathy","volume":"20","author":"Kim","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2024101011101680100_CIT0044","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.3390\/ijms23084447","article-title":"Thrombin preconditioning improves the therapeutic efficacy of mesenchymal stem cells in severe intraventricular hemorrhage induced neonatal rats","volume":"23","author":"Jung","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2024101011101680100_CIT0045","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/ijms24010881","article-title":"iPSC-derived MSCs are a distinct entity of MSCs with higher therapeutic potential than their donor-matched parental MSCs","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2024101011101680100_CIT0046","first-page":"3945403","article-title":"Promising therapeutic strategies for mesenchymal stem cell-based cardiovascular regeneration: from cell priming to tissue engineering","volume":"2017","author":"Ji","year":"2017","journal-title":"Stem Cells Int"},{"issue":"12","key":"2024101011101680100_CIT0047","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1164\/rccm.201101-0055OC","article-title":"Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants","volume":"183","author":"Laughon","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"15","key":"2024101011101680100_CIT0048","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"2024101011101680100_CIT0049","doi-asserted-by":"crossref","first-page":"e0120893","DOI":"10.1371\/journal.pone.0120893","article-title":"Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy","volume":"10","author":"Park","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2024101011101680100_CIT0050","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.1038\/s41598-018-25902-x","article-title":"Hypothermia broadens the therapeutic time window of mesenchymal stem cell transplantation for severe neonatal hypoxic ischemic encephalopathy","volume":"8","author":"Ahn","year":"2018","journal-title":"Sci Rep"},{"issue":"2","key":"2024101011101680100_CIT0051","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/STROKEAHA.112.679092","article-title":"Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage","volume":"44","author":"Ahn","year":"2013","journal-title":"Stroke"},{"issue":"4","key":"2024101011101680100_CIT0052","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"issue":"1","key":"2024101011101680100_CIT0053","doi-asserted-by":"crossref","first-page":"F37","DOI":"10.1136\/fn.87.1.F37","article-title":"Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome","volume":"87","author":"Murphy","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"2024101011101680100_CIT0054","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/ten.teb.2011.0488","article-title":"Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements","volume":"18","author":"Doorn","year":"2012","journal-title":"Tissue Eng Part B Rev"},{"issue":"8","key":"2024101011101680100_CIT0055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3727\/096368909X471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant"},{"issue":"7","key":"2024101011101680100_CIT0056","doi-asserted-by":"crossref","first-page":"e0132919","DOI":"10.1371\/journal.pone.0132919","article-title":"Optimal route for mesenchymal stem cells transplantation after severe intraventricular hemorrhage in newborn rats","volume":"10","author":"Ahn","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"2024101011101680100_CIT0057","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.ajpath.2014.08.010","article-title":"Intranasal versus intraperitoneal delivery of human umbilical cord tissue-derived cultured mesenchymal stromal cells in a murine model of neonatal lung injury","volume":"184","author":"Liu","year":"2014","journal-title":"Am J Pathol"},{"issue":"1","key":"2024101011101680100_CIT0058","doi-asserted-by":"crossref","first-page":"e52419","DOI":"10.1371\/journal.pone.0052419","article-title":"Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"2024101011101680100_CIT0059","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/thoraxjnl-2012-202323","article-title":"Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia","volume":"68","author":"Pierro","year":"2013","journal-title":"Thorax"},{"issue":"11","key":"2024101011101680100_CIT0060","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1164\/rccm.200902-0179OC","article-title":"Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats","volume":"180","author":"van Haaften","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"2024101011101680100_CIT0061","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3727\/096368915X689640","article-title":"Optimal timing of mesenchymal stem cell therapy for neonatal intraventricular hemorrhage","volume":"25","author":"Park","year":"2016","journal-title":"Cell Transplant"},{"issue":"11-12","key":"2024101011101680100_CIT0062","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.3727\/096368911X565038a","article-title":"Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats","volume":"20","author":"Chang","year":"2011","journal-title":"Cell Transplant"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/13\/10\/941\/59705475\/szae060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/13\/10\/941\/59705475\/szae060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:29:04Z","timestamp":1728559744000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/13\/10\/941\/7730904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,10,10]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szae060","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,8,9]]}}}