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[2024]072"],"award-info":[{"award-number":["Z.K. [2024]072"]}]},{"name":"Guizhou Provincial Basic Research Program","award":["Z.K. [2021]008"],"award-info":[{"award-number":["Z.K. [2021]008"]}]},{"name":"PhD Fund of Scientific Research Foundation of Affiliated Hospital of Zunyi Medical University","award":["2020-03"],"award-info":[{"award-number":["2020-03"]}]},{"name":"\u201cThousand-talents\u201d for High-level Innovative Talents Training Project in Guizhou Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eukaryotic translation initiation factor 6 (eIF6) plays a crucial role in 60S ribosome biogenesis and protein translation, as well as in hypertrophic scar formation, but its potential role in epithelialization is still poorly understood. Herein, we found that eIF6 negatively correlated with the wound healing process. Mice with genetically knockdown eIF6 (eIF6+\/\u2212) showed faster re-epithelization as shown by the longer tongue of the newly formed epidermis. Furthermore, eIF6 ablation accelerated the wound healing process by targeting basal keratinocytes in the eIF6 keratinocyte-conditional knockout (eIF6f\/+; Krt5-Cre+) mice. Mechanistically, keratin 6B, an important wound-activated protein, was significantly upregulated in eIF6f\/+; Krt5-Cre+ mice skin as proved by RNA-seq, western immunoblots, and immunofluorescence staining. Moreover, an elevated level of KRT6B and accelerated proliferative capacity were also observed in stable knockdown eIF6 HaCaT cells. Taken together, eIF6 downregulation could accelerate epithelialization by upregulating KRT6B expression and promoting keratinocyte proliferation. Our results for the first time indicate that eIF6 might be a novel target to regulate re-epithelialization.<\/jats:p>","DOI":"10.1093\/stcltm\/szae064","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T18:30:12Z","timestamp":1723660212000},"page":"1101-1112","source":"Crossref","is-referenced-by-count":11,"title":["eIF6 modulates skin wound healing by upregulating keratin 6B"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1979-6290","authenticated-orcid":false,"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, The First Affiliated Hospital of Shenzhen University , Shenzhen 518035 ,","place":["People\u2019s Republic of China"]},{"name":"Department of Burn and Wound Repair Surgery, Guangdong Provincial People\u2019s Hospital , Guangzhou 510080 ,","place":["People\u2019s Republic of 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Pra","sequence":"additional","affiliation":[{"name":"Section of Human Histology & Embryology, Department of Surgery, Dentistry, Paediatrics & Obstetrics, University of Verona , Verona, Venetia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, The First Affiliated Hospital of Shenzhen University , Shenzhen 518035 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou 317000 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Taizhou 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