{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:47:34Z","timestamp":1791902854621,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21bm0104001h0009 and 21bm0204004h0009"],"award-info":[{"award-number":["21bm0104001h0009 and 21bm0204004h0009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cerebral organoids (COs) in cell replacement therapy offer a viable approach to reconstructing neural circuits for individuals suffering from stroke or traumatic brain injuries. Successful transplantation relies on effective engraftment and neurite extension from the grafts. Earlier research has validated the effectiveness of delaying the transplantation procedure by 1 week. Here, we hypothesized that brain tissues 1 week following a traumatic brain injury possess a more favorable environment for cell transplantation when compared to immediately after injury. We performed a transcriptomic comparison to differentiate gene expression between these 2 temporal states. In controlled in vitro conditions, recombinant human progranulin (rhPGRN) bolstered the survival rate of dissociated neurons sourced from human induced pluripotent stem cell-derived COs (hiPSC-COs) under conditions of enhanced oxidative stress. This increase in viability was attributable to a reduction in apoptosis via Akt phosphorylation. In addition, rhPGRN pretreatment before in vivo transplantation experiments augmented the engraftment efficiency of hiPSC-COs considerably and facilitated neurite elongation along the host brain\u2019s corticospinal tracts. Subsequent histological assessments at 3 months post-transplantation revealed an elevated presence of graft-derived subcerebral projection neurons\u2014crucial elements for reconstituting neural circuits\u2014in the rhPGRN-treated group. These outcomes highlight the potential of PGRN as a neurotrophic factor suitable for incorporation into hiPSC-CO-based cell therapies.<\/jats:p>","DOI":"10.1093\/stcltm\/szae066","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T20:00:19Z","timestamp":1727553619000},"page":"1113-1128","source":"Crossref","is-referenced-by-count":11,"title":["Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4414-6277","authenticated-orcid":false,"given":"Keitaro","family":"Yamagami","sequence":"first","affiliation":[{"name":"Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University , Kyoto ,","place":["Japan"]},{"name":"Department of Neurosurgery, Kyushu University Graduate School of Medical Sciences, Kyushu University , Fukuoka 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