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To assess potential paracrine contribution, the secretome of cardiopoiesis conditioned versus na\u00efve human mesenchymal stromal cells was decoded by directed proteomics augmented with machine learning and systems interrogation. Cardiopoiesis doubled cellular protein output generating a distinct secretome that segregated the conditioned state. Altering the expression of 1035 secreted proteins, cardiopoiesis reshaped the secretome across functional classes. The resolved differential cardiopoietic secretome was enriched in mesoderm development and cardiac progenitor signaling processes, yielding a cardiovasculogenic profile bolstered by upregulated cardiogenic proteins. In tandem, cardiopoiesis enhanced the secretion of immunomodulatory proteins associated with cytokine signaling, leukocyte migration, and chemotaxis. Network analysis integrated the differential secretome within an interactome of 1745 molecules featuring prioritized regenerative processes. Secretome contribution to the repair signature of cardiopoietic cell-treated infarcted hearts was assessed in a murine coronary ligation model. Intramyocardial delivery of cardiopoietic cells improved the performance of failing hearts, with undirected proteomics revealing 50 myocardial proteins responsive to cell therapy. Pathway analysis linked the secretome to cardiac proteome remodeling, pinpointing 17 cardiopoiesis-upregulated secretome proteins directly upstream of 44% of the cell therapy-responsive cardiac proteome. Knockout, in silico, of this 22-protein secretome-dependent myocardial ensemble eliminated indices of the repair signature. Accordingly, in vivo, cell therapy rendered the secretome-dependent myocardial proteome of an infarcted heart indiscernible from healthy counterparts. Thus, the secretagogue effect of cardiopoiesis transforms the human stem cell secretome, endows regenerative competency, and upregulates candidate paracrine effectors of cell therapy-mediated molecular restitution.<\/jats:p>","DOI":"10.1093\/stcltm\/szae067","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:41:35Z","timestamp":1726094495000},"page":"1144-1159","source":"Crossref","is-referenced-by-count":4,"title":["Decoded cardiopoietic cell secretome linkage to heart repair biosignature"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-8544","authenticated-orcid":false,"given":"Armin","family":"Garmany","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Center for Regenerative Biotherapeutics, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Marriott Heart Disease Research Program, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Mayo Clinic Alix School of Medicine, Regenerative Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic , Rochester, MN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-3782","authenticated-orcid":false,"given":"D Kent","family":"Arrell","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Center for Regenerative Biotherapeutics, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Marriott Heart Disease Research Program, Mayo Clinic , Rochester, MN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-4539","authenticated-orcid":false,"given":"Satsuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Center for Regenerative Biotherapeutics, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Marriott Heart Disease Research Program, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Section of Geriatric Medicine & Gerontology, Department of Medicine, Mayo Clinic , Rochester, MN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1197","authenticated-orcid":false,"given":"Ryounghoon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Center for Regenerative Biotherapeutics, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Marriott Heart Disease Research Program, Mayo Clinic , Rochester, MN ,","place":["United 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